PMID: 9183698Jun 9, 1997Paper

Efferent connections of the internal globus pallidus in the squirrel monkey: II. Topography and synaptic organization of pallidal efferents to the pedunculopontine nucleus

The Journal of Comparative Neurology
E ShinkY Smith

Abstract

The first objective of the present study was to verify whether projections from regions of the internal pallidum (GPi) that receive inputs from different functional areas of the striatum remain segregated at the level of the pedunculopontine nucleus (PPN) in squirrel monkeys. Second, we analyzed the ultrastructural features and synaptic organization of pallidal terminals in contact with PPN neurons. This was achieved by performing iontophoretic injections of biotinylated dextran amine (BDA) in different regions of the GPi. The animals were pooled into three groups on the basis of the location of the injection sites and the resulting distribution of retrogradely labelled striatal neurons. The experimental groups were divided as follows: group 1: injections in the dorsal one-third of the GPi, retrograde labelling in the head and body of the caudate nucleus ("associative striatum"); group 2: injections in the ventrolateral two-thirds of the GPi, retrograde labelling in the postcommissural region of the putamen ("sensorimotor striatum"); and group 3: injections in the rostromedial pole of the GPi, retrograde labelling in the ventral striatum ("limbic striatum"). These injections led to the anterograde labelling of varicose fibers t...Continue Reading

Citations

Sep 5, 2008·Journal of Neurophysiology·Matthew D Johnson, Cameron C McIntyre
Aug 20, 2003·The European Journal of Neuroscience·Kazuya SaitohKaoru Takakusaki
Mar 19, 2008·Experimental Brain Research·Moran WeinbergerJonathan O Dostrovsky
Oct 14, 2005·Journal of Neurology·Masaru Matsumura

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