Efferent projections of a physiologically characterized region of the inferior colliculus of the young adult CBA mouse

The Journal of the Acoustical Society of America
R D FrisinaD A Klotz

Abstract

The present investigation is part of an ongoing series of studies aimed at discerning the neural bases of presbycusis. Presbycusis is a sensory perceptual disorder involving loss of high-pitch hearing and reduced ability to process biologically relevant acoustic signals in noisy environments. The purpose of the present experiment was to delineate the efferent projections of a functionally characterized region of the dorsomedial inferior colliculus (IC, auditory midbrain) in young, adult CBA mice. The CBA strain's progressive loss of hearing over its lifespan approximates many aspects of the mild-to-moderate hearing loss experienced by a significant number of humans suffering from presbycusis. Focal, iontophoretic injections of HRP were made in the 18-24 kHz region of dorsomedial IC of the CBA strain following physiological mapping experiments. Serial sections were reacted with a chromagen, counterstained and examined for anterogradely labeled fibers and boutons. Efferent projections were observed ipsilaterally in: medial and ventral divisions of the medial geniculate body (MGB); middle layers of the superior colliculus; central gray; and external nucleus (E), dorsal cortex (DC) and central nucleus of IC. Contralaterally, labele...Continue Reading

References

Mar 15, 1979·The Journal of Comparative Neurology·S B EdwardsB E Stein
Jul 15, 1975·The Journal of Comparative Neurology·D K Morest
Sep 15, 1992·The Journal of Comparative Neurology·K M Hofstetter, G Ehret
Jul 22, 1992·The Journal of Comparative Neurology·J F WillottS L McFadden
Jan 1, 1990·Acta Oto-laryngologica. Supplementum·A C DavisA Parving
Oct 1, 1990·The Journal of Comparative Neurology·J F Willott, L S Bross
Mar 19, 1986·Brain Research·T H González HernándezR Ferres-Torres
Apr 1, 1986·Neuroscience·V MeiningerP Derer
Jun 1, 1989·The Journal of Comparative Neurology·R D FrisinaM L Zettel
Sep 8, 1987·The Journal of Comparative Neurology·E CoveyJ B Kobler
Jun 1, 1972·The Annals of Otology, Rhinology, and Laryngology·L G Johnsson, J E Hawkins
Oct 1, 1974·The Laryngoscope·H F SchuknechtC Y Ota
Apr 1, 1966·Experimental Neurology·R Y Moore, J M Goldberg
May 1, 1974·The Laryngoscope·H F Schuknecht, J C Kirchner
Jun 1, 1969·The Journal of Comparative Neurology·E W Powell, J B Hatton
Jan 1, 1984·Archives of Oto-rhino-laryngology·T RahkoP Karma
Jan 1, 1980·Audiology : Official Organ of the International Society of Audiology·K R Henry, R A Chole
Dec 1, 1980·The Journal of Comparative Neurology·R A AndersenM M Merzenich
Feb 1, 1995·The Journal of the Acoustical Society of America·J D PearsonJ L Fozard
Mar 15, 1993·The Journal of Comparative Neurology·J F WillottS L McFadden
Aug 1, 1997·Journal of Comparative Physiology. A, Sensory, Neural, and Behavioral Physiology·J P WaltonW E O'Neill
Jul 1, 1991·The European Journal of Neuroscience·Gerd SchullerJohn H. Casseday
Nov 1, 1962·The Journal of Speech and Hearing Disorders·R HINCHCLIFFE
Feb 1, 1980·American Industrial Hygiene Association Journal·L H RoysterJ D Royster

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Citations

Apr 1, 2006·Experimental Brain Research·Hans C DringenbergJennifer Murdoch
Apr 25, 2007·Journal of the Association for Research in Otolaryngology : JARO·Martha L ZettelRobert D Frisina
Nov 27, 1999·Hearing Research·A M JimenezB L Lonsbury-Martin
Sep 1, 2015·Hearing Research·Charles C LeeKazuo Imaizumi
Aug 7, 2004·The Journal of the Acoustical Society of America·Henry SimonJoseph P Walton

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