Efferocytosis and Atherosclerosis: Regulation of Phagocyte Function by MicroRNAs

Trends in Endocrinology and Metabolism : TEM
Amir TajbakhshAmirhossein Sahebkar

Abstract

There is evidence of the critical role of efferocytosis, the clearance of apoptotic cells (ACs) by phagocytes, in vascular cell homeostasis and protection against atherosclerosis. Specific microRNAs (miRs) can regulate atherogenesis by controlling the accumulation of professional phagocytes (e.g., macrophages) and nonprofessional phagocytes (i.e., neighboring tissue cells with the ability to acquire a macrophage-like phenotype) within the arterial wall, the differentiation of phagocytes into foam cells, the efferocytosis of apoptotic foam cells by phagocytes, and the phagocyte-mediated inflammatory response. A better understanding of the mechanisms involved in miR-regulated phagocyte function might lead to novel therapeutic antiatherosclerotic strategies. In this review, we try to shed light on the relationship between miRs and cellular players in the process of efferocytosis in the context of atherosclerotic plaque and their potential as molecular targets for novel antiatherosclerotic therapies.

Citations

Nov 27, 2019·Journal of Clinical Medicine·Amir TajbakhshAmirhossein Sahebkar
Oct 29, 2019·Current Cancer Drug Targets·Milad AshrafizadehSaeed Samarghandian
Oct 2, 2019·Cells·Milad AshrafizadehGautam Sethi
Oct 15, 2019·Nutrition and Cancer·Milad AshrafizadehSaeed Samarghandian
Apr 1, 2020·Cellular & Molecular Biology Letters·Mehri Bemani NaeiniAmirhossein Sahebkar
Feb 19, 2021·Frontiers in Endocrinology·Lili WangPing Yao
Mar 21, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Wujun ChenDongming Xing
Jun 2, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Amir TajbakhshAmirhossein Sahebkar

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