Efferocytosis: molecular mechanisms and pathophysiological perspectives

Immunology and Cell Biology
Seyed Mohammad Gheibi HayatAmirhossein Sahebkar

Abstract

During the life of a human being, several tons of apoptotic cells and debris are produced. These apoptotic particles should be cleared quickly and accurately from the body, as they may lose their membrane integrity with the probability of leakage of cytotoxic materials and other intracellular antigens into the environment. The action of removing apoptotic particles occurs by a process called efferocytosis. Efferocytosis is a highly regulated balance among a set of find-me, eat-me and don't-eat-me signals. Efferocytosis is accompanied by a suppression of the immune system that can explain its negative role in cancer. Additionally, defects in this process can lead to different diseases. In this review, we aim to describe the mechanism of efferocytosis and evaluate its association with the development of autoimmune diseases, airway inflammation, atherosclerosis and cancer to open a new window for the treatment of these diseases.

References

Dec 6, 1997·Nature·R E VollI Girkontaite
Apr 14, 1999·Cell Death and Differentiation·V A FadokP M Henson
Apr 5, 2001·The New England Journal of Medicine·M J Walport
Oct 10, 2001·Current Biology : CB·P M HensonV A Fadok
Oct 25, 2002·Immunobiology·Marina Botto, Mark J Walport
Nov 20, 2003·Nature Reviews. Molecular Cell Biology·Alfred I Tauber
Dec 6, 2003·The Journal of Allergy and Clinical Immunology·Anne-Cécile RimaniolMarc Humbert
May 25, 2004·Science·Rikinari HanayamaShigekazu Nagata
Aug 31, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Carlos MatuteMaría Domercq
Dec 20, 2007·The Journal of Biological Chemistry·Christoph PeterKirsten Lauber
Jan 29, 2008·Current Medicinal Chemistry·Takayuki MatsumotoKatsuo Kamata
Mar 26, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·David R GudeSarah Spiegel
Jul 15, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Aisleen McCollIan Dransfield
Sep 11, 2009·Nature·Christopher Gregory
Dec 8, 2009·American Journal of Respiratory and Critical Care Medicine·Changsuk MoonJihee Lee Kang
Jan 21, 2010·Cancer Research·Laetitia AymericLaurence Zitvogel
Apr 7, 2010·Proceedings of the National Academy of Sciences of the United States of America·Roselynn Rodriguez-ManzanetVijay K Kuchroo
Sep 2, 2010·The Journal of Experimental Medicine·Kodi S Ravichandran
Apr 27, 2011·Journal of Cellular Physiology·Wei Li
Mar 28, 2012·Proceedings of the National Academy of Sciences of the United States of America·Stephen B WillinghamIrving L Weissman
Mar 28, 2012·Proceedings of the National Academy of Sciences of the United States of America·Badreddin EdrisMatt van de Rijn
Feb 26, 2013·Molecular Cell·Sean P CullenSeamus J Martin
Jun 5, 2013·Chest·Alexandra L McCubbrey, Jeffrey L Curtis
Jul 26, 2013·PloS One·Sarah E LutzEliana Scemes
Nov 5, 2013·Cold Spring Harbor Perspectives in Biology·Greg Lemke
Feb 1, 2014·Nature Reviews. Immunology·Ivan K H PoonKodi S Ravichandran
Feb 12, 2014·Molecular and Cellular Biology·Chihiro NishiShigekazu Nagata
May 24, 2014·Circulation Research·Gwendalyn J Randolph
Jul 2, 2014·The Journal of Clinical Investigation·Thomas B ThornleyTerry B Strom

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Citations

Sep 1, 2019·Current Pharmaceutical Design·Eskandar TaghizadehAmirhossein Sahebkar
Sep 6, 2019·Cellular Oncology (Dordrecht)·Seyed Mohammad Gheibi HayatAmirhossein Sahebkar
Aug 21, 2019·BioFactors·Shahla KoraniAmirhossein Sahebkar
Jul 4, 2019·Clinical Reviews in Allergy & Immunology·Fereshte AbdolmalekiAmirhossein Sahebkar
May 7, 2020·Cell Communication and Signaling : CCS·Yunxiang ZhouAnwen Shao
May 22, 2020·Expert Opinion on Drug Delivery·Seyed Mohammad Gheibi HayatAmirhossein Sahebkar
Apr 7, 2019·Biochemical Society Transactions·Lois R GrantAndrew Devitt
Apr 1, 2020·Cellular & Molecular Biology Letters·Mehri Bemani NaeiniAmirhossein Sahebkar
Oct 30, 2020·Cells·Nina D AnfinogenovaDmitriy N Atochin
Aug 20, 2019·International Journal of Pharmaceutics·Seyed Mohammad Gheibi HayatAmirhossein Sahebkar
Mar 16, 2021·Frontiers in Immunology·Irma Husain, Xunrong Luo
Mar 21, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Wujun ChenDongming Xing
Aug 28, 2021·International Journal of Molecular Sciences·Christina MertensMichaela Jung
Nov 16, 2021·Molecular Medicine Reports·Yifan ZhangPing Liu

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