PMID: 8971288Dec 1, 1996Paper

Effervescent and standard formulations of ranitidine--a comparison of their pharmacokinetics and pharmacology

Alimentary Pharmacology & Therapeutics
R G WatsonK Kersey

Abstract

An effervescent formulation of ranitidine may be absorbed faster and achieve a faster onset of action than conventional tablet form. The aim of this study was to compare the effects of effervescent formulations of ranitidine with equivalent dose standard tablets, in terms of intragastric pH and plasma pharmacokinetics in the initial 6 h following dosing. Fifteen fasting healthy males, aged 18-31 (mean 29) years, were each randomly given, at weekly intervals, 150 mg standard and effervescent ranitidine and 300 mg standard and effervescent ranitidine. Ambulatory gastric pH was performed and plasma drug levels measured at regular intervals. Plasma ranitidine levels increased more rapidly with both effervescent formulations compared with standard tablets as indicated by mean area under curve (AUC) at 1 h (P < 0.001). However, the pH profiles produced by all four treatments were similar with a steep rise in pH at 40-60 min to give a sustained level of pH 7 for the following 5 h. The effervescent formulations produced a transient rise in pH immediately following dosing, and for 300 mg this rise was significantly different at 10-20 min compared with the standard tablet (median pH 4.75 vs. 2.3, P < 0.05). Plasma drug levels increase mo...Continue Reading

Citations

Dec 24, 2004·Antimicrobial Agents and Chemotherapy·Susan L FordDaniel S Stein
Jun 20, 1998·BMJ : British Medical Journal·J P GalmicheC Scarpignato
Feb 21, 2006·Clinical Pharmacokinetics·Mary Beth WireScott Studenberg
Mar 13, 2003·Journal of Clinical Periodontology·Bernd WaschulRenate Deinzer
Apr 28, 2006·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Mark J SheltonGeoffrey Yuen

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