Efficacy and clinical predictors of response to rTMS treatment in pharmacoresistant obsessive-compulsive disorder (OCD): a retrospective study

BMC Psychiatry
Reza RostamiM A Salehinejad

Abstract

Application of repetitive transcranial magnetic stimulation (rTMS) for treating obsessive-compulsive disorder (OCD) has been promising and approved by the Food and Drug Administration in 2018, but effects differ between patients. Knowledge about clinical predictors of rTMS response may help to increase clinical efficacy but is not available so far. In a retrospective study, we investigated the efficacy of rTMS over the dorsolateral prefrontal cortex (DLPFC) or supplementary motor area (SMA) in 65 pharmaco-resistant OCD outpatients recruited for rTMS treatment from July 2015 to May 2017. Patients received either SMA rTMS (n = 38) or bilateral DLPFC rTMS (n = 27) in case of reporting higher affective and depressive symptoms in addition to the primary OCD symptoms. OCD symptoms and depression/anxiety states were measured at baseline (before the 1st session) and after the 20th session of rTMS. Additionally, we performed a binary logistic regression analysis on the demographic and clinical variables based on the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) 3-factor and 2-factor models and individual items to investigate potential predictors of rTMS response. Patients' scores in Y-BOCS and Beck anxiety/depression inventories were s...Continue Reading

References

Nov 1, 1989·Archives of General Psychiatry·W K GoodmanD S Charney
Jan 1, 1985·Behaviour Research and Therapy·P M Salkovskis
Feb 1, 1994·Psychiatry Research·S W KimK M Hoover
Jul 22, 1998·Behaviour Research and Therapy·S Rachman
Aug 24, 2000·The Journal of Neuropsychiatry and Clinical Neurosciences·F A KozelM S George
Apr 3, 2001·Annual Review of Neuroscience·E K Miller, J D Cohen
May 3, 2001·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·J C KeelE M Wassermann
Jul 19, 2001·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·E M Wassermann, S H Lisanby
Dec 13, 2001·Current Opinion in Neurobiology·N Picard, P L Strick
Apr 3, 2002·Psychiatry Research·Steffen MoritzIver Hand
Mar 12, 2003·Journal of Behavior Therapy and Experimental Psychiatry·W A ArrindellM G T Kwee
Aug 2, 2003·Harvard Review of Psychiatry·Christine Lochner, Dan J Stein
Jun 1, 1961·Archives of General Psychiatry·A T BECKJ ERBAUGH
Mar 31, 2004·Trends in Cognitive Sciences·Adam R AronRussell A Poldrack
Jun 29, 2005·The International Journal of Neuropsychopharmacology·Antonio MantovaniSimone Rossi
Jul 12, 2005·Journal of Anxiety Disorders·Ovsanna T LeyferJanet Woodruff-Borden
Mar 1, 2006·Progress in Neuro-psychopharmacology & Biological Psychiatry·Stefano Pallanti, Leonardo Quercioli
Mar 29, 2006·The Journal of Clinical Psychiatry·Helen Blair SimpsonMichael R Liebowitz
Aug 31, 2006·The International Journal of Neuropsychopharmacology·Felipe FregniAlvaro Pascual-Leone
Jul 24, 2007·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Ritsuko HanajimaYoshikazu Ugawa
Feb 24, 2009·Behaviour Research and Therapy·Jessica R Grisham, Alishia D Williams
Aug 12, 2009·Lancet·Jonathan S AbramowitzDean McKay
Nov 4, 2009·Archives of General Psychiatry·Ben J HarrisonNarcís Cardoner
Dec 6, 2011·Trends in Cognitive Sciences·Mohammed R Milad, Scott L Rauch
May 23, 2012·Handbook of Clinical Neurology·Donovan MaustMichael E Thase
Jul 14, 2012·CNS Spectrums·Stefano PallantiLeonardo Quercioli
Jul 19, 2014·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Jean-Pascal LefaucheurLuis Garcia-Larrea
Aug 20, 2014·Journal of Behavior Therapy and Experimental Psychiatry·Ragnar P ÓlafssonÁrni Kristjánsson
Feb 24, 2015·Journal of Clinical Epidemiology·Peter C Austin, Ewout W Steyerberg
Sep 1, 2015·Annals of Physical and Rehabilitation Medicine·Wanalee KlomjaiAlexandra Lackmy-Vallée
Oct 7, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Katharine DunlopJonathan Downar
Feb 3, 2016·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·David Mataix-ColsHelen Blair Simpson
Sep 9, 2016·European Psychiatry : the Journal of the Association of European Psychiatrists·P VellosoM C do Rosário
Sep 30, 2016·Frontiers in Human Neuroscience·Tamas MinarikPaul Sauseng
Dec 14, 2016·Journal of Anxiety Disorders·Laura B Bragdon, Meredith E Coles

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May 18, 2021·Brain and Neuroscience Advances·Mohammad Ali SalehinejadMichael A Nitsche

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