Efficacy and costs of 3 anesthetic regimens in the prevention of postoperative nausea and vomiting

Journal of Clinical Anesthesia
Sinikka PurhonenMarkku Hynynen

Abstract

The aim of the study was to compare the antiemetic efficacy and costs associated with 3 different anesthesia regimens used in gynecologic laparoscopy. This was a randomized, controlled study. The study was conducted at a university hospital. We studied 150 ASA physical status I or II patients, undergoing elective gynecologic laparoscopy with general anesthesia. Patients were allocated into the following 3 groups: group P-preoperative placebo tablet, propofol induction, propofol-air/O2 maintenance; group I + O-preoperative 8-mg ondansetron tablet, thiopental induction, isoflurane-N2O maintenance; group I (control)-preoperative placebo tablet, thiopental induction, isoflurane-N2O maintenance. The frequency of postoperative nausea and vomiting (PONV), number needed to treat to prevent PONV, and the costs of the anesthetic drugs to prevent PONV in one additional patient were evaluated. The frequency of PONV within the 24-hour study period was lowest in group I + O (P, 38%; I + O, 33%; and I, 59%; P < 0.05 I + O vs I). The number needed to treat was 5 in group P and 4 in group I + O, compared with group I. The median costs of anesthetic drugs to prevent PONV in one additional patient were $65 in group P and dollar 68 in group I + O,...Continue Reading

References

Jan 1, 1996·European Journal of Anaesthesiology·A Klockgether-RadkeD Kettler
Feb 1, 1997·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·J A AlhashemiK A Hull
Feb 16, 2000·British Journal of Anaesthesia·I SmithI A Johnson
Jun 11, 2004·The New England Journal of Medicine·Christian C ApfelUNKNOWN IMPACT Investigators

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Citations

Feb 12, 2008·Journal of Minimally Invasive Gynecology·Jon I EinarssonAdalbjorn Thorsteinsson
Jun 16, 2016·Arquivos De Gastroenterologia·Uirá Fernandes TeixeiraFábio Luiz Waechter
Jan 10, 2014·Anesthesiology·Philip J Peyton, Christine Yx Wu
Aug 2, 2012·Anesthesiology·J Lance Lichtor, Frances Chung
Oct 19, 2012·Current Opinion in Anaesthesiology·J Lance Lichtor
Jan 27, 2011·Journal of Perioperative Practice·Marios Hadjipavlou, Craig R Bailey
Oct 20, 2020·The Cochrane Database of Systematic Reviews·Stephanie WeibelPeter Kranke
Jul 11, 2007·Current Opinion in Anaesthesiology

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