Efficacy and cytokine modulating effects of tacrolimus in systemic lupus erythematosus: a review.

Journal of Biomedicine & Biotechnology
Kam Hon Yoon

Abstract

Systemic lupus erythematosus (SLE) is a complex systemic autoimmune disease with involvement of both B cells and cytotoxic T lymphocytes and several cytokines aberrations. Standard therapy for SLE has its limitations. Tacrolimus, a novel calcineurin inhibitor with potent immunosuppressive effects, has been shown in the recent years to be effective in SLE therapy. This paper serves to collate the experimental and clinical data on the efficacy of tacrolimus in the treatment of SLE and lupus nephritis. Tacrolimus as a key component of multitarget therapy in SLE is also discussed. The immunocytokine modulatory effects of tacrolimus are also reviewed with reference to SLE. It can be concluded that tacrolimus has an established role in the management of SLE.

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Citations

Nov 30, 2011·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Jaume Alijotas-ReigMiquel Vilardell-Tarrés
Jan 6, 2016·Nature Reviews. Rheumatology·C C Mok
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Sep 4, 2016·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Chi Chiu Mok
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Oct 11, 2017·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Paras JosheeElizabeth A Grunfeld
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Sep 25, 2016·Proceedings of the National Academy of Sciences of the United States of America·Rongsheng E WangFeng Wang
Feb 20, 2019·Clinical Rheumatology·Mai KawazoeToshihiro Nanki

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Methods Mentioned

BETA
biopsy

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