Efficacy and dermal toxicity analysis of Sildenafil citrate based topical hydrogel formulation against traumatic wounds

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Shweta KulshresthaMitra Basu

Abstract

Sildenafil Citrate (SC) is a US FDA approved drug, have been used to treat wounds due to their nitric oxide (NO) stimulating activity in the tissue. But, there are only a few studies about the topical effect of this drug on the healing of traumatic wounds. The purpose of the study is to develop topical SC hydrogel (SCH) and to investigate its dermal toxicity and wound healing efficacy in Sprague dawley rats. In the present study, hydrogel containing SC showed no change and stable with respect to pH, homogeneity, spreadability and effiecient encapsulation. SEM analysis represents the uniform texture of the SCH. Acute dermal toxicity of the SCH exhibited that the formulations are devoid of any toxic effects and safe to be used. Percentage of wound contraction, re-epithelization, tensile strength and biochemical parameters such as hydroxyproline, collagen, total protein and NO content at dermal level prove the wound healing efficacy of prepared SCH. In addition, histopathology confirmed that the SCH promoted re-epithelization, collagen synthesis, deposition and regeneration of skin appendages. Results demonstrated that SCH has no dermal toxicity and promoted wound healing. Thus, prepared SCH shows promising skin wound healing prop...Continue Reading

References

Apr 1, 1988·Analytical Biochemistry·H D Hill, J G Straka
Jun 10, 1980·Clinica Chimica Acta; International Journal of Clinical Chemistry·C A Edwards, W D O'Brien
Jun 1, 1996·The Journal of Surgical Research·M R SchafferA Barbul
Aug 8, 2002·Current Pharmaceutical Biotechnology·Bishara S AtiyehKusai A El-Musa
Jul 21, 2004·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Robert D GalianoGeoffrey C Gurtner
Nov 17, 2004·British Journal of Plastic Surgery·Nedim SarifakiogluGürcan Aslan
Nov 24, 2004·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Wanda A Dorsett-Martin
Feb 18, 2005·Acta Pharmacologica Sinica·Jian-dong Luo, Alex F Chen
Jun 1, 2005·International Journal of Clinical Practice·G JacksonI Osterloh
Apr 6, 2006·The Laryngoscope·Kristopher HartJose Pizarro
Jan 9, 2009·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Stephan BarrientosMarjana Tomic-Canic
Jan 14, 2009·Journal of Clinical Pharmacy and Therapeutics·H PerkN Delibas
Feb 19, 2009·Langenbeck's Archives of Surgery·Hayrullah DericiYesim Erbil
Oct 25, 2011·Journal of Ayurveda and Integrative Medicine·Vidya SabalePrafulla Sabale
Oct 22, 2013·Pharmacognosy Magazine·Abdul Wadood KhanJaved Ali
Mar 4, 2014·BioMed Research International·Anu RahalKuldeep Dhama
Aug 31, 2014·Bosnian Journal of Basic Medical Sciences·Koray GürsoyVildan Fidanci
Dec 5, 2014·Science Translational Medicine·Sabine A EmingMarjana Tomic-Canic
May 18, 2016·Pharmaceutical Biology·Guilherme F CaetanoMarco Andrey Cipriani Frade
Sep 21, 2016·Proceedings of the National Academy of Sciences of the United States of America·Yun XiaoMilica Radisic
Nov 10, 2016·Anais Brasileiros De Dermatologia·Ana Cristina de Oliveira GonzalezAlena Ribeiro Alves Peixoto Medrado
Jan 4, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ankit TanwarHaider Ali Khan
Jul 4, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jawun ChoiJae-Won Seol

❮ Previous
Next ❯

Citations

Jul 1, 2020·Acta Diabetologica·Wael Abu DayyihHisham Y Al-Matubsi
Sep 27, 2019·Current Pharmaceutical Design·Gitika A DhingraManju Nagpal
May 6, 2020·Marine Drugs·Tingting YanSidong Li
Jul 1, 2020·The Journal of Investigative Dermatology·Maya Ben-Yehuda GreenwaldSabine Werner
Jan 29, 2021·International Journal of Biological Macromolecules·Dongying ZhangSidong Li
Mar 15, 2021·Archives of Dermatological Research·Rafael A C SouzaThaís R Sudbrack
Apr 12, 2021·Toxicology in Vitro : an International Journal Published in Association with BIBRA·J FrankovaJ Ulrichova
Jul 17, 2021·International Journal of Biological Macromolecules·Murugan Prasathkumar, Subramaniam Sadhasivam

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.