Efficacy and efficiency of gastric electrical stimulation with short pulses in the treatment of vasopressin-induced emetic responses in dogs

Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society
G SongJ D Z Chen

Abstract

The aim of this study was to determine the most effective and efficient anti-emetic parameters of short-pulse gastric electrical stimulation (GES) in dogs. Seven female beagle dogs implanted with four pairs of gastric electrodes were studied in eight randomized sessions (saline, vasopressin, and six GES sessions with different parameters). Each session consisted of four 20-min recordings of gastric slow waves and symptoms. In sessions 1 and 2, saline and vasopressin, respectively, were infused during the second 20-min period. The protocol of the other six sessions was the same as session 2 except that GES was continuously applied. It was found that: (1) vasopressin induced gastric dysrhythmia and emetic response (P < 0.01, anova); (2) short-pulse GES with a frequency of 14 or 40 Hz and pulse width of 0.1 or 0.3 ms, but not 0.6 ms was able to reduce symptoms induced by vasopressin; (3) short-pulse GES with a pulse width of 0.3 ms was the most effective in preventing vasopressin-induced symptoms; (4) none of the tested GES methods improved vasopressin-induced gastric dysrhythmia. We conclude that vasopressin induces gastric dysrhythmia and symptoms. Short-pulse GES with a pulse width of 0.3 ms and frequency of 14 Hz is most effec...Continue Reading

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Citations

Aug 19, 2007·Diseases of the Colon and Rectum·Geng-Qing SongJiande D Z Chen
Jul 14, 2006·Current Treatment Options in Gastroenterology·Jing Zhang, J D Z Chen
Apr 1, 2010·Neuromodulation : Journal of the International Neuromodulation Society·Geng-Qing SongJiande D Z Chen
Oct 14, 2011·Neuromodulation : Journal of the International Neuromodulation Society·Geng-Qing Song, Jiande D Z Chen
May 20, 2009·World Journal of Gastroenterology : WJG·Bin YangJiande D Z Chen
Jan 22, 2011·World Journal of Gastroenterology : WJG·Mauro Bortolotti
Sep 19, 2008·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Y Lei, J D Z Chen
Nov 23, 2007·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·G-Q SongJ D Z Chen
Mar 4, 2009·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·W L Hasler
Mar 3, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J SongJ D Z Chen
Jun 27, 2014·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·X YuX Hou
Jul 30, 2014·IEEE Transactions on Bio-medical Engineering·Hooman HafeziGeorge M Savage
Apr 14, 2016·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·C C HornD M Rosenberg
Dec 4, 2010·Autonomic Neuroscience : Basic & Clinical·Ji-Hong ChenJiande D Z Chen
Jun 11, 2016·Neuromodulation : Journal of the International Neuromodulation Society·Timothy R AngeliGregory O'Grady
Jul 28, 2016·Autonomic Neuroscience : Basic & Clinical·Carey D Balaban, Bill J Yates
Apr 2, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Shiying Li, Jiande D Z Chen
May 11, 2018·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·G SongR W McCallum

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