Efficacy and follow-up of transcatheter aortic valve implantation in patients with radiation-induced aortic stenosis

Open Heart
Marina DijosStéphane Lafitte

Abstract

To investigate transcatheter aortic valve implantation (TAVI) feasibility, effectiveness and safety in radiation-induced aortic valve stenosis cases. 198 consecutive patients referred for TAVI were prospectively enrolled. They were divided into two groups: patients with a history of chest radiation therapy with suspected radiation-induced valvular disease (RXT) and others with suspected degenerative aortic valve stenosis (NRXT). Procedural, early and mid-term clinical outcomes were compared. Of the 198 patients enrolled in our study, 9.6% qualified for inclusion in the RXT group. A comparison of baseline characteristics revealed that patients with RXT were younger than patients with NRXT (68.3 vs 82.5 years; p<0.05) and exhibited a lower surgical risk score (Euroscore: 7.1% vs 21.8%; p<0.05) and a higher frequency of hostile thorax and porcelain aorta (52.6% vs 28.5%; p<0.05; 63.2% vs 10.6%; p<0.05, respectively). In both groups, the implantation success rate was high and the 30-day safety end point acceptable (RXT: 94.7% and 83.3%; NRXT: 93.9% and 75.6%, respectively). At 6 months, overall mortality was significantly lower in the RXT group (0% vs 18%; p=0.048). In patients suffering from radiation-induced aortic valve stenosis...Continue Reading

Citations

Dec 15, 2015·Heart·Dorothy M GujralSanjeev Bhattacharyya
May 6, 2019·Current Treatment Options in Oncology·Michael E LayounMaros Ferencik
May 28, 2019·Journal of the American Heart Association·Anthony A Bavry
Jun 5, 2019·Current Treatment Options in Cardiovascular Medicine·Katherine Lee ChuyDipti Gupta
Jan 24, 2020·Journal of Cardiac Surgery·Onur B DolmaciAbdullah Kaya
Jun 5, 2020·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Alexandra C MurphyMatias B Yudi
Dec 29, 2020·International Journal of Cardiology·Riyad Y KherallahSrikanth Koneru
Feb 9, 2021·European Heart Journal Cardiovascular Imaging·Stefania RosminiArjun K Ghosh
Apr 17, 2021·Frontiers in Cardiovascular Medicine·Eric H YangCezar Iliescu
Sep 7, 2021·Journal of the American Heart Association·Eve Belzile-Dugas, Mark J Eisenberg

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Methods Mentioned

BETA
coronary artery bypass
coronary artery obstruction
dissection

Software Mentioned

Statel

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