Abstract
A variety of plant products have been recognized for their antifungal activity and recently have attracted food industry attention for their efficacy in controlling postharvest fungal decay of fruits. The antifungal activity of perillaldehyde (PAE) was evaluated against Aspergillus niger, a known cause of grape spoilage, and possible mechanisms were explored. PAE showed notable antifungal activity against A. niger, with a minimum inhibitory concentration (MIC) and a minimum fungicidal concentration (MFC) of 0.25 and 1 μl/ml, respectively. The accumulation of mycelial biomass was also inhibited by PAE in a dose-dependent manner, completely inhibiting mycelial growth at 1 μl/ml. In vivo data confirmed that the vapour treatment of grapes with various concentrations of PAE markedly improved control of A. niger and suppressed natural decay. Concentrations of PAE of 0.075 μl/ml air showed the greatest inhibition of fungal growth compared to the controls. Further experiments indicated that PAE activated a membrane-active mechanism that inhibits ergosterol synthesis, increases membrane permeability (as evidenced by extracellular pH and conductivity measurements), and disrupts membrane integrity, leading to cell death. Our findings sugg...Continue Reading
References
Feb 1, 1994·European Journal of Immunology·S SchulzS Ansorge
Jun 1, 1996·Anti-cancer Drugs·J KarlsonS Linder
Jan 1, 1997·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·T SuzukiK Takata
May 17, 2001·Antimicrobial Agents and Chemotherapy·M D De BackerH Vanden Bossche
Dec 12, 2001·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·C Pina-VazJ Martinez-de-Oliveira
Jan 30, 2002·Trends in Molecular Medicine·Antonella LupettiSteven Kelly
Mar 28, 2002·Applied and Environmental Microbiology·A UlteeR Moezelaar
Jul 27, 2002·Journal of Natural Products·Paul McGeadyDavid A Logan
Jun 18, 2004·The Journal of Antimicrobial Chemotherapy·Meher ParveenHitoshi Iwahashi
May 6, 2008·International Journal of Food Microbiology·Neslihan DikbasFikrettin Sahin
Oct 29, 2008·Evidence-based Complementary and Alternative Medicine : ECAM·N ItoT Hanawa
Jul 11, 2009·Journal of Medical Microbiology·Eugénia PintoLígia Salgueiro
Feb 16, 2011·International Journal of Food Microbiology·Jun TianYouwei Wang
Jul 5, 2011·European Journal of Medicinal Chemistry·Hasnae BendahaMohammed Bellaoui
Jan 25, 2012·PloS One·Jun TianYouwei Wang
Jan 26, 2012·Journal of Natural Products·Lars DuelundOle G Mouritsen
Sep 19, 2012·Food Microbiology·Nereide Serafim Timóteo dos SantosEvandro Leite de Souza
Dec 25, 2012·Biochimica Et Biophysica Acta·Jaeyong ChoDong Gun Lee
Dec 26, 2012·Food Chemistry·Fei SunKaoshan Chen
Jan 1, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kelly Samara de Lira MotaEdeltrudes de Oliveira Lima
Jul 3, 2013·International Journal of Food Microbiology·Larissa Lima de SousaEvandro Leite de Souza
Feb 5, 2014·Food Chemistry·Nengguo TaoHaien Zhou
Feb 20, 2014·Journal of Food Science·Nivedita SonkerN N Tripathi
May 1, 2012·Food Chemistry·Peng JinChien Y Wang
Citations
Oct 31, 2015·Journal of Agricultural and Food Chemistry·Weilin JianXinwei Li
Aug 16, 2016·BMC Genomics·Qiuli OuYangGuoxing Jing
Oct 30, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Cheryl A HobbsShim-Mo Hayashi
Sep 14, 2016·Journal of Agricultural and Food Chemistry·Jun TianXue Peng
Nov 18, 2016·Protoplasma·Shiwen DouNengguo Tao
Feb 23, 2017·Applied Microbiology and Biotechnology·Hui TianJun Tian
Feb 23, 2020·Microorganisms·Zhong ZhangDov Prusky
Mar 19, 2020·Foodborne Pathogens and Disease·Qi ZhouKang Yuan
Jun 25, 2020·Investigative Ophthalmology & Visual Science·Yiqun FanJing Lin
Apr 14, 2018·Frontiers in Microbiology·Yuan WangTianli Yue
Nov 15, 2018·Frontiers in Microbiology·Tuanwei ChenHetong Lin
Jan 11, 2020·Frontiers in Microbiology·Su QuJun Tian
Feb 28, 2020·International Journal of Molecular Sciences·Chao PanJun Tian
Mar 6, 2018·Frontiers in Microbiology·Qiuli OuYangMiaoling Zhang
Jun 12, 2018·Frontiers in Microbiology·Man ZhangJun Tian
Nov 16, 2020·Journal of Applied Microbiology·Jiaqi YanWensuo Jia
Sep 29, 2019·Chemosphere·Mi FengJiahua Zhou
Jan 3, 2021·Food Chemistry·Chi ZhangJun Tian
Mar 23, 2021·Critical Reviews in Food Science and Nutrition·Famous ErhunmwunseeJun Tian
May 4, 2021·Food Science and Biotechnology·Jingru ZhangShaoying Zhang
Jun 3, 2021·Journal of Fungi·Qiuli OuYangNengguo Tao
Jul 16, 2021·Frontiers in Microbiology·Jorge MartínezIdoia Postigo
Sep 18, 2021·Phytotherapy Research : PTR·Fahimeh NourbakhshVahid Soheili