Efficacy and safety of a 7.5% icodextrin peritoneal dialysis solution in patients treated with automated peritoneal dialysis

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
Joerg PlumJosé C Divino Filho

Abstract

In a randomized, prospective, multicenter study, we compared the safety, efficacy, and metabolic effects of a 7.5% icodextrin solution (Extraneal) with a 2.27% glucose solution for long dwell exchanges in patients undergoing automated peritoneal dialysis. Thirty-nine stable patients on automated peritoneal dialysis were randomized to receive either icodextrin (n = 20) or glucose 2.27% solution (n = 19). The study included a 2-week baseline period followed by a 12-week icodextrin treatment phase and a 2-week follow-up period when switching back to glucose. The average net ultrafiltration during the long dwell period was 278 +/- 43 mL/d for the icodextrin group and -138 +/- 81 mL/d for the control group (P < 0.001). The higher ultrafiltration volume with icodextrin was associated with higher creatinine (2.59 +/- 0.09 mL/min versus 2.16 +/- 0.11 mL/min) and urea (2.67 +/- 0.09 mL/min versus 2.28 +/- 0.12 mL/min) peritoneal clearances for the long dwell (both P < 0.001). Ultrafiltration rate per mass of carbohydrate absorbed was +5.2 +/- 1.2 microL/min/g in the icodextrin group and -5.5 +/- 2.8 microL/min/g in the glucose group (P < 0.001). In the icodextrin group, there was a decrease in serum sodium and chloride compared with bas...Continue Reading

References

Sep 1, 1990·Kidney International·O HeimbürgerB Lindholm
Sep 1, 1996·Kidney International·M M Ho-dac-PannekeetR T Krediet
Nov 1, 1996·Journal of the American Society of Nephrology : JASN·B A WaradyE C Kohaut
Mar 1, 1997·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·N PosthumaA J Donker
Jun 6, 1997·Journal of Chromatography. B, Biomedical Sciences and Applications·R A BurkeT R Shockley
Dec 16, 1998·Kidney International·S J DaviesG I Russell
Jan 19, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·D N Churchill
Jun 26, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·G WoodrowA M Brownjohn
Jun 1, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·G WoodrowA M Brownjohn
Dec 15, 2000·Kidney International·Y UedaC Van Ypersele De Strihou

❮ Previous
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Citations

Nov 8, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Eric GoffinOlivier Devuyst
Dec 13, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Vittorio E AndreucciJoel D Kopple
Apr 8, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Mark WrightJohn Turney
Jun 17, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Andreas VychytilUNKNOWN Extraneal Peritonitis Study Group
Feb 23, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Raymond T Krediet
Mar 16, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Yeoungjee ChoKathryn J Wiggins
Sep 20, 2012·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·M HamrahianL A Juncos
Feb 19, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Allison DartGuido Filler
Oct 28, 2008·Expert Opinion on Drug Metabolism & Toxicology·Darshika Chhabra, Kevin Nash
Feb 12, 2004·Kidney International. Supplement·Anand VardhanRaymond T Krediet
Sep 17, 2002·Kidney International. Supplement·Allan J Collins
Sep 17, 2002·Kidney International. Supplement·Ali K Abu-AlfaSalim Mujais
Sep 17, 2002·Kidney International. Supplement·Marsha WolfsonSalim Mujais
Sep 17, 2002·Kidney International. Supplement·Ram GokalSalim Mujais
Sep 17, 2002·Kidney International. Supplement·Roberto Pecoits-FilhoBengt Lindholm
Aug 19, 2015·Journal of Clinical Pharmacy and Therapeutics·P Ditsawanon, P Aramwit
Feb 1, 2013·International Journal of Nephrology·Periklis DousdampanisJoanne M Bargman
Mar 31, 2015·Clinical Kidney Journal·Arkom NongnuchAndrew Davenport
May 15, 2016·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Sharon RoussoElizabeth A Harvey
Aug 18, 2016·Artificial Organs·Naoya YamaguchiTakashi Horiuchi
Oct 31, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Marsha WolfsonUNKNOWN Icodextrin Study Group
May 31, 2017·Nutrients·Bernd Stegmayr
May 13, 2011·Nephron. Clinical Practice·Graham Woodrow, Simon Davies
Nov 18, 2017·BMC Nephrology·Graham WoodrowAndrew Neil Pyrah
Mar 29, 2014·The Cochrane Database of Systematic Reviews·Yeoungjee ChoKathryn J Wiggins
Dec 5, 2002·Pharmacoepidemiology and Drug Safety
Oct 25, 2007·Nature Clinical Practice. Nephrology·Pieter M ter Wee, Frans J van Ittersum
Oct 21, 2018·Clinical Journal of the American Society of Nephrology : CJASN·Vasilios VaiosRajiv Agarwal
Sep 10, 2003·Drugs·James E Frampton, Greg L Plosker
Oct 14, 2018·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Xuemei LiMark R Marshall
Dec 2, 2010·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Hualin QiJun Ma
Mar 4, 2014·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Alp AkonurJohn K Leypoldt
Sep 4, 2014·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Alp AkonurJohn Leypoldt
Nov 2, 2013·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Alp AkonurJohn K Leypoldt
Apr 5, 2016·Medicine·Tae Ik ChangUNKNOWN Yonsei Associate Network CHronic Kidney Disease Trial (YACHT) investigators
Apr 15, 2020·Seminars in Dialysis·Timothy W R DoultonIndranil Dasgupta
Jul 17, 2018·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Chieko HiguchiHiroshi Sakura
Feb 18, 2020·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Dharshan RangaswamyKamal Sud
Oct 1, 2008·NDT Plus·Trijntje T CnossenJeroen P Kooman
Jul 7, 2018·Journal of Nephrology·Silvio BorrelliUNKNOWN Study group Peritoneal Dialysis of Italian Society of Nephrology
Jul 5, 2017·International Urology and Nephrology·Periklis DousdampanisKonstantina Trigka
Feb 18, 2020·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Chang Huei ChenIsaac Teitelbaum
Oct 27, 2018·The Cochrane Database of Systematic Reviews·Htay HtayYeoungjee Cho
Mar 30, 2021·Clinical Kidney Journal·David A Jaques, Andrew Davenport

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