Efficacy and safety of a live canine adenovirus-vectored rabies virus vaccine in swine

Vaccine
Ye LiuRongliang Hu

Abstract

Rabies infections in swine have been reported occasionally in recent years in certain geographic locations. Although a protective vaccine consisting of inactivated rabies virus is available for use in swine, searching for a more economically viable formulation for use in developing countries is always a priority. This work describes the testing of a canine adenovirus that expresses a rabies viral epitope (CAV-2-E3Delta-RGP) in a porcine rabies model. The data presented here show that the recombinant viral vaccine was effective in protecting swine against rabies if administered intramuscularly, but not orally or intranasally, and that protection was probably related to the development of a humoral response that lasted at least 28 weeks. Following vaccination, no behavioral abnormalities were observed in vaccinated swine and virus particles were not detected in either tissues or body fluids, indicating that this formulation was safe. The recombinant virus stimulated an effective level of antibody response in the immunized swine after a single intramuscular inoculation.

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Citations

Sep 30, 2009·PLoS Neglected Tropical Diseases·Hildegund C J Ertl
Sep 16, 2009·Journal of Virological Methods·María Mercedes SeguraMiguel Chillón
Mar 7, 2009·The Journal of General Virology·Marion SzelechowskiBernard Klonjkowski
May 23, 2015·Applied Microbiology and Biotechnology·R CastroA S Coroadinha
Jul 18, 2012·Human Gene Therapy Methods·María Mercedes SeguraMiguel Chillón
Sep 28, 2021·Frontiers in Veterinary Science·José M RojasVerónica Martín

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