PMID: 9646621Jul 1, 1998Paper

Efficacy and safety of a new cholesterol synthesis inhibitor, atorvastatin, in comparison with simvastatin and pravastatin, in subjects with hypercholesterolemia

The Netherlands Journal of Medicine
B H WolffenbuttelD Black

Abstract

High levels of total and LDL-cholesterol are associated with an increased risk of atherosclerotic vascular disease. Lowering of serum cholesterol levels by pharmacologic intervention with inhibitors of cholesterol synthesis, the so-called statins, reduces the incidence of cardiovascular events in subjects with and without atherosclerotic manifestations. In a 16-week, multicenter, randomized, open-label cross-over study we compared the efficacy and safety of the new compound atorvastatin for reducing LDL-cholesterol with simvastatin or pravastatin. Following a 4-week placebo-controlled baseline period patients with LDL-cholesterol between 4.1 and 6.2 mmol/l and serum triglycerides below 3.4 mmol/l were randomly assigned to treatment either with 5 or 20 mg atorvastatin, or with 10 mg simvastatin or 20 mg pravastatin once daily for 4 weeks. After a placebo-washout period of 4-6 weeks, patients switched to the alternate treatment. At the end of weeks 3 and 4 of each study phase the serum concentrations of lipid parameters and apolipoproteins as well as safety parameters were determined. A total of 78 subjects entered the study. Treatment with 5 mg atorvastatin reduced total and LDL-cholesterol by 21 and 27%, respectively, which was...Continue Reading

Citations

May 12, 2010·Journal of Clinical Pharmacy and Therapeutics·T-C WengS-H Tai
Mar 16, 2001·Expert Opinion on Pharmacotherapy·M H MoghadasianJ J Frohlich
Jun 10, 2004·The Annals of Pharmacotherapy·Michael G Kendrach, Maisha Kelly-Freeman
Nov 22, 2014·The Cochrane Database of Systematic Reviews·Stephen P AdamsJames M Wright

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