Abstract
Alternatives to skin preparation with conventional preoperative antiseptics are required because of adverse reactions and the potential emergence of resistance. Here, we present 2 phase 2 studies of ZuraGard (ZG), a novel formulation of isopropyl alcohol and functional excipients developed for preoperative skin antisepsis. Microbial skin flora on abdominal and inguinal sites in healthy volunteers were quantitatively assessed following application of ZG versus a negative control (ZV) and a chlorhexidine/alcohol preparation, Chloraprep (CP). In trial 1, ZG administered for both recommended and abbreviated application times was compared with CP and ZV via bacterial reductions at 10 minutes, and 6 hours, 12 hours, and 24 hours following application. In trial 2, the 10-minute postapplication responder rates (RRs) for ZG, participants with abdominal ≥2 log10 per cm2, and inguinal ≥3 log10 per cm2 reductions in colony-forming units (CFU) were compared to RRs of participants treated with CP. In trial 1, ZG at the recommended application time reduced mean bacterial counts by ~3.18 log10 CFU/cm2 and ~2.98 log10 CFU/cm2 at abdominal and inguinal sites, respectively. Qualitatively similar reductions were observed for the abbreviated ZG app...Continue Reading
References
Dec 2, 1999·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·K B KirklandD J Sexton
Jul 20, 2002·Journal of Infusion Nursing : the Official Publication of the Infusion Nurses Society·John S HibbardAnn R Brady
Mar 16, 2007·Public Health Reports·R Monina KlevensDenise M Cardo
Jun 15, 2007·The Journal of Allergy and Clinical Immunology·Lene Heise GarveyBent Husum
Nov 6, 2007·The Journal of Antimicrobial Chemotherapy·Karen SmithIain S Hunter
May 15, 2008·The Journal of Antimicrobial Chemotherapy·Jann-Tay WangShan-Chwen Chang
Dec 5, 2008·Journal of the American Geriatrics Society·Keith S KayeKenneth E Schmader
Feb 15, 2011·Infectious Disease Clinics of North America·Deverick J Anderson
Jun 2, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Andie S LeeStephan Harbarth
Jul 27, 2012·The Journal of Antimicrobial Chemotherapy·Carolyne HornerMark Wilcox
Sep 18, 2012·PloS One·Matthias Maiwald, Edwin S Y Chan
Oct 23, 2012·Surgical Infections·Todd R VogelStephen F Lowry
Jun 5, 2013·Journal of the American Geriatrics Society·Linda T LiAanand D Naik
Oct 15, 2013·American Journal of Surgery·Angela GibsonGregory Kennedy
Jul 30, 2014·Clinical and Experimental Immunology·M T KrishnaA P Williams
Nov 8, 2014·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Deverick J AndersonKeith S Kaye
Mar 12, 2015·Surgical Infections·Feroze Sidhwa, Kamal M F Itani
May 8, 2015·Journal of Anaesthesiology, Clinical Pharmacology·Eleni MokaAthina Vadalouca
May 8, 2015·Journal of Anaesthesiology, Clinical Pharmacology·Claude Abdallah
Sep 13, 2015·ANZ Journal of Surgery·Gary SharpMichael Rose
Sep 28, 2016·The Journal of Hospital Infection·G Kampf
Nov 7, 2016·The Lancet Infectious Diseases·Benedetta AllegranziUNKNOWN WHO Guidelines Development Group
Dec 5, 2016·Journal of the American College of Surgeons·Kristen A BanTherese M Duane
May 4, 2017·JAMA Surgery·Sandra I Berríos-TorresUNKNOWN Healthcare Infection Control Practices Advisory Committee
Jun 9, 2017·Clinical Microbiology Reviews·Deborah A WilliamsonBenjamin P Howden
Sep 28, 2017·The Lancet Infectious Diseases·Matthias Maiwald, Andreas F Widmer
May 31, 2018·MBio·Katherine HardyMark Webber
Jun 9, 2018·Current Infectious Disease Reports·Gregory R Madden, Costi D Sifri