Efficacy and safety of abobotulinumtoxinA for upper limb spasticity in children with cerebral palsy: a randomized repeat-treatment study.

Developmental Medicine and Child Neurology
Mauricio R DelgadoDysport in PUL study group

Abstract

To assess the efficacy and safety of repeat abobotulinumtoxinA injections in reducing upper limb spasticity in children with cerebral palsy (CP). This was a double-blind, repeat-cycle study (NCT02106351) in children with CP (2-17y). Children were randomized to receive 2U/kg (control), 8U/kg, or 16U/kg abobotulinumtoxinA injections into the target muscle group (wrist or elbow flexors) and additional muscles alongside occupational therapy via a home-exercise therapy program (HETP; minimum five 15min sessions/wk). Children received 8U/kg or 16U/kg plus HETP in cycles 2 to 4. During cycle 1, 210 children (126 males, 84 females; mean age [SD] 9y [4y 5mo], range 2-17y; n=70/group) had at least one upper limb abobotulinumtoxinA injection and 209 complied with the HETP. At week 6 of cycle 1, children in the 8U/kg or 16U/kg groups had significantly lower Modified Ashworth scale scores versus the 2U/kg group (primary outcome: treatment differences of -0.4 [p=0.012] and -0.7 [p<0.001] respectively). All groups improved on Physician Global Assessment and children in all groups achieved their treatment goals at least as expected. Therapeutic benefits were sustained during cycles 2 to 4; muscular weakness was the only treatment-related adver...Continue Reading

References

Feb 1, 1987·Physical Therapy·R W Bohannon, M B Smith
Jul 1, 1993·Journal of Pediatric Orthopedics·L A KomanT Mulvaney
Apr 1, 1997·Developmental Medicine and Child Neurology·R PalisanoB Galuppi
Feb 20, 2002·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·R N BoydH K Graham
Jan 31, 2009·Clinical Rehabilitation·Lynne Turner-Stokes
Oct 21, 2009·Journal of Rehabilitation Medicine·Marie HolmefurLena Krumlinde-Sundholm
Nov 17, 2009·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Florian HeinenGuy Molenaers
Mar 20, 2010·Archives of Physical Medicine and Rehabilitation·Jean-Michel GraciesMauricio R Delgado
Jul 17, 2010·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·D FehlingsUNKNOWN Cerebral Palsy Institute
Nov 26, 2013·Lancet·Allan ColverPeter O D Pharoah
May 16, 2014·Journal of Children's Orthopaedics·Daoud MakkiMatthew Nixon
Sep 16, 2017·Journal of Child Neurology·Mauricio R DelgadoPhilippe Picaut
Sep 12, 2018·Developmental Medicine and Child Neurology·Jenny Hedberg-GraffLena Krumlinde-Sundholm
Jan 12, 2019·Developmental Medicine and Child Neurology·Véronique F P PlasschaertCornelia H M Van den Ende
Jul 2, 2019·Paediatric Drugs·Iqbal MultaniKerr Graham

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Citations

Feb 8, 2021·Developmental Medicine and Child Neurology·Kerr Graham
Jul 21, 2021·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·D A KrasavinaY I Ivanov

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