Efficacy and safety of acupuncture at a single BL1 acupoint in the treatment of moderate to severe dry eye disease: Protocol for a randomized, controlled trial

Medicine
Xue ZhangWenzeng Zhu

Abstract

Dry eye disease (DED) is a very common disease. Although several current treatments offer some symptomatic relief, moderate to severe DED is still difficult to cure at present. Acupuncture may be effective for DED via its promotion of tear secretion and ability to improve symptoms, but evidence of its effectiveness is limited. The aim of this study is to evaluate the effect of acupuncture versus artificial tears in moderate to severe DED. A total of 120 participants with moderate to severe DED will be randomly assigned to either an acupuncture group or an artificial tear group at a ratio of 1:1. Participants in the acupuncture group will undergo treatments on a single BL1 acupuncture point 3 times per week for 8 weeks. Participants in the control group will use artificial tears 4 times per day for 8 weeks. The primary outcome will be the change from baseline in a mean Schirmer-I test (SIT) at week 8. The secondary outcomes will include the visual analog score (VAS) for the improvement of ocular symptoms, the ocular surface disease index (OSDI), the tear film break-up time (TBUT), and corneal fluorescein staining (CFS) at weeks 4, 8, and 32. Acupuncture acceptance will be evaluated at week 8. Adverse events will also be monitore...Continue Reading

References

Sep 1, 1984·Survey of Ophthalmology·J W Shell
May 29, 1999·Statistical Methods in Medical Research·J L Schafer
May 18, 2000·Archives of Ophthalmology·R M SchiffmanB L Reis
Jul 18, 2003·Ophthalmology·Rhett M SchiffmanWalton Sumner
Nov 15, 2006·Cornea·Ashley BehrensUNKNOWN Dysfunctional tear syndrome study group
Jun 20, 2008·Journal français d'ophtalmologie·C BaudouinB Arnould
Aug 19, 2009·Clinical Ophthalmology·Johnny L Gayton
Mar 27, 2010·Acta Ophthalmologica·Myeong Soo LeeEdzard Ernst
Nov 13, 2010·Acta Ophthalmologica·Mi-Suk ShinTae-Hun Kim
Dec 9, 2010·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Ju-Hyun JeonSun-Mi Choi
Feb 26, 2011·Journal of Evidence-based Medicine·Hugh MacPhersonUNKNOWN STRICTA Revision Group
Jan 11, 2013·BMJ : British Medical Journal·An-Wen ChanDavid Moher
May 12, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Lei YangHui Song
Oct 30, 2016·European Journal of Ophthalmology·Pierre-Yves RobertChristophe Baudouin
May 12, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Xue ZhangZhishun Liu
Jul 25, 2017·The Ocular Surface·Anthony J BronDavid A Sullivan
Oct 23, 2017·Ophthalmology·Praneetha Thulasi, Ali Reza Djalilian
Oct 23, 2017·Ophthalmology·Stephen C Pflugfelder, Cintia S de Paiva

❮ Previous
Next ❯

Citations

Aug 25, 2019·Journal of Clinical Medicine·Yu-Kai KuoChing-Li Tseng
May 20, 2021·Current Opinion in Ophthalmology·Rhiya MittalAnat Galor

❮ Previous
Next ❯

Software Mentioned

SPSS
PASS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.