Efficacy and safety of adalimumab in the treatment of non-infectious uveitis: a meta-analysis and systematic review

Drug Design, Development and Therapy
Shuai MingBo Lei

Abstract

To summarize updated evidences on the efficacy and safety of adalimumab (ADA) in the treatment of patients with non-infectious uveitis. A systematic search between January 2000 and September 2017 was conducted using PubMed, Embase, and Cochrane libraries. We investigated control of inflammation, improvement of visual acuity (VA), corticosteroid-sparing effect, and adverse events (AEs) or serious adverse events. Three randomized clinical trials (RCTs) and 20 non-RCTs were included and analyzed. The pooled proportions of inflammation control were 74% (95% CI 64%-82%) and 79% (95% CI 69%-87%) in groups of ≤6- and ≥12-months follow-up durations. No significant difference was found between the two groups (χ2 = 0.920, p = 0.337). Analysis of subgroups classified by degree of being treatment-naïve for anti-TNFα agents showed the inflammation control reached a high of 87% (95% CI 80%-92%) when subjects were "almost naïve" to anti-TNFα before ADA treatment. VA was improved by three or more lines in 41.3% (52/126) eyes, and was equal to or better than the baseline in 88.8% (142/160) eyes. Corticosteroid sparing was observed in 82.0% (91/111) of the patients; among them, 48.8% (40/82) discontinued use of corticosteroid completely. Minor d...Continue Reading

Citations

May 17, 2019·Expert Opinion on Drug Delivery·Francine Behar-Cohen
Apr 28, 2020·Journal of Ophthalmic Inflammation and Infection·Fernanda Nicolela Susanna, Carlos Pavesio
May 20, 2020·Ophthalmology·Jennifer LeeDebra A Goldstein
Nov 3, 2020·Drug Discovery Today·Matthew CollinsHanieh Khalili
Feb 3, 2021·Yonsei Medical Journal·Sung Eun ParkMin Kim
Nov 12, 2020·Journal of Clinical Medicine·Mathilde LeclercqDavid Saadoun
Sep 18, 2021·Acta Ophthalmologica·Carlyn V KouwenbergJoke H de Boer
Nov 20, 2021·Frontiers in Pharmacology·Qi JiangWenru Su

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