Efficacy and safety of adjunctive levetiracetam therapy in pediatric intractable epilepsy

Pediatric Neurology
Yun Jin LeeJoon Soo Lee

Abstract

To investigate the efficacy and safety of levetiracetam adjunctive therapy in childhood intractable epilepsy, data were reviewed for 130 children who had >or=4 seizures per month, whose seizures were intractable to an initial >or=2 antiepileptic drugs, and who could be monitored for at least 6 months after levetiracetam add-on. Reduction in seizure frequency and related variables were investigated. Sixty-two of the 130 patients (48%) showed a seizure reduction of >or=50%, and 28 patients (22%) became seizure-free. A reduction in seizures by >or=50% was observed in 33/64 in children with partial seizures (52%) and in 29/66 children with generalized seizures (44%). Efficacy did not differ significantly among seizure types. Overall efficacy was unaffected by abnormalities evident from magnetic resonance imaging, by mental retardation, or by maintenance dose of levetiracetam. The mean maintenance dose of levetiracetam was 47.0mg/kg per day (S.D. = +/- 29.7), and mean follow-up duration was 13.4 months (S.D. =+/- 8.7). No demographic features differed significantly between patients with seizure freedom and without seizure remission. Levetiracetam was discontinued in 24 children at last visit (retention rate, 82%). The most common co...Continue Reading

References

Dec 24, 2002·Seizure : the Journal of the British Epilepsy Association·Karl O NakkenSvein I Johannessen
Jan 27, 2004·Seizure : the Journal of the British Epilepsy Association·Marco MulaJosemir W A S Sander
Mar 11, 2004·Seizure : the Journal of the British Epilepsy Association·Maw J Tan, Richard E Appleton
Jun 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Berkley A LynchBruno Fuks
Aug 12, 2004·Neurology·Andrew NicolsonDavid F Smith
Jan 12, 2005·Seizure : the Journal of the British Epilepsy Association·L LagaeB Ceulemans
May 25, 2005·Seizure : the Journal of the British Epilepsy Association·S GrossoP Balestri
Sep 27, 2005·Seizure : the Journal of the British Epilepsy Association·Joachim OppElisabeth Korn-Merker
Jan 30, 2007·Seizure : the Journal of the British Epilepsy Association·D PeakeS Philip
Mar 21, 2007·Seizure : the Journal of the British Epilepsy Association·S GrossoP Balestri
Apr 20, 2007·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Celina von StuelpnagelGerhard Kluger
Oct 24, 2007·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Petra M C CallenbachOebele F Brouwer

❮ Previous
Next ❯

Citations

Sep 17, 2013·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Caroline Dureau-PourninUNKNOWN EULEV study group
Mar 19, 2014·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Kang Min ParkSung Eun Kim
Oct 1, 2014·Pediatric Neurology·Hyo Jeong KimHeung Dong Kim
Aug 31, 2014·Pediatric Neurology·Rana İşgüderAycan Ünalp
Jul 21, 2015·Pediatrics International : Official Journal of the Japan Pediatric Society·Sosuke YoshikawaHiroshi Tamai
Feb 16, 2016·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Alexis ArzimanoglouJürgen Bentz
Nov 20, 2012·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Hadassa Goldberg-SternAviva Phatal-Valevski
Nov 9, 2011·Seminars in Pediatric Neurology·Shaun Hussain, Raman Sankar
Dec 17, 2014·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Xue-fei FengNong Xiao
Dec 16, 2011·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·M Doumbia-OuattaraP Berquin
Mar 2, 2016·PloS One·Oluwaseun EgunsolaHelen Mary Sammons
Jan 7, 2011·Expert Opinion on Pharmacotherapy·Alberto VerrottiFrancesco Chiarelli
Oct 4, 2020·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Kelly D HaqueMarianne E Nellis
Nov 14, 2020·Epilepsy & Behavior : E&B·Camila Cortes, Carla Manterola

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.