Efficacy and safety of an anti-retroviral combination regimen including either efavirenz or lopinavir-ritonavir with a backbone of two nucleoside reverse transcriptase inhibitors

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
P PanagopoulosH Giamarellou

Abstract

The efficacy and safety of a combination regimen including either efavirenz or lopinavir-ritonavir was examined in a cohort of 65 patients positive for human immunodeficiency virus-1 (HIV-1). Both the efavirenz (n = 33, 18 anti-retroviral naive) and lopinavir-ritonavir (n = 32, 15 naive) regimens achieved significant changes from baseline CD4 cell counts and HIV RNA levels after 108 weeks (p < 0.01). Despite diminished immunological and virological parameters at study entry, the lopinavir-ritonavir group showed greater virological effects than the efavirenz group after 108 weeks (median change 3.3 log(10), interquartile range (IQR) 2.2-3.8 log(10) vs. 2.4 log(10), IQR 0.9-3.3 log(10), respectively, p 0.004). Use of lopinavir-ritonavir, in contrast to use of efavirenz, was associated with significant hypertriglyceridaemia.

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Citations

Jul 14, 2010·AIDS Research and Human Retroviruses·Beatriz GrinsztejnMonika Peeters
Apr 28, 2007·HIV Medicine·A CalmyUNKNOWN Aquitaine Cohort, Australian HIV Observational Database and St Vincent's Hospital Cohort study groups
May 2, 2012·Journal of Chemotherapy·A PapadopoulosG Touloumi
Sep 2, 2009·Journal of the International Association of Physicians in AIDS Care : JIAPAC·María Jesús Pérez-ElíasSantiago Moreno
Jun 13, 2020·Journal of Chemotherapy·Periklis PanagopoulosDimitrios Papazoglou
Aug 5, 2020·Drug Delivery and Translational Research·Malobika Chakravarty, Amisha Vora

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