Abstract
Hospitalized patients are subject to acute illness and stress which may impact appetite or weight. Loss of appetite may lead to increased morbidity or mortality. Medications such as dronabinol, megestrol, and mirtazapine are used for weight gain in the outpatient setting; however, there is limited information about safety or effectiveness when initiated inpatient. To analyze the effectiveness and safety of appetite-stimulating medications in hospitalized patients. This was a retrospective cohort study of hospitalized patients initiated on dronabinol, megestrol, or mirtazapine for appetite. The primary outcome was change in meal intake between drug initiation and discontinuation. Secondary outcomes included documented improvement in appetite, change in weight and various laboratory parameters, and incidence of adverse effects. A total of 38 patients met inclusion criteria, and mirtazapine was most commonly used (42%). There was no significant difference between groups of appetite-stimulating medications with regard to mean change in meal intake, weight, albumin, or documented improvement in diet. Within groups, each agent showed numerical improvement in percentage meal intake, with a mean change from initiation to discontinuatio...Continue Reading
References
Feb 1, 1995·Journal of Pain and Symptom Management·J E BealK V Shepard
May 1, 1995·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·C S BlaumM A Fiatarone
Mar 1, 1995·The Medical Clinics of North America·C M Reife
Apr 17, 1999·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·M A van Bokhorst-De van der SchuerP A van Leeuwen
Oct 19, 2001·CNS Drug Reviews·S A Anttila, E V Leinonen
May 15, 2002·The Journal of Pediatrics·Valerie EubanksChristopher M Makris
May 3, 2006·The Journal of Clinical Psychiatry·Markus LaimerChristoph F Ebenbichler
Aug 23, 2008·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·William J EvansStefan D Anker
Dec 25, 2009·CNS Drugs·Norio WatanabeUNKNOWN MANGA (Meta-Analysis of New Generation Antidepressants) Study Group
Feb 18, 2010·British Journal of Cancer·M PressoirP Bachmann
Jan 13, 2011·JPEN. Journal of Parenteral and Enteral Nutrition·Charles MuellerUNKNOWN American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.) Board of Directors
Apr 29, 2011·Medicina clínica·Alberto HerrejónAnna Anguera
Apr 2, 2013·The Cochrane Database of Systematic Reviews·Vicente Ruiz GarciaSylvia Bort-Marti
Oct 10, 2013·The International Journal of Eating Disorders·Alin AndriesRené Klinkby Støving
May 2, 2014·Swiss Medical Weekly·Philipp SchützUlrich Keller
Jul 19, 2014·Journal of Psychiatric Practice·David McMahon, Sheldon H Preskorn
Mar 2, 2016·HIV/AIDS : Research and Palliative Care·Melissa E Badowski, Sarah E Perez
Citations
Jun 10, 2020·Biomolecules·Thomas Murphy, Bernard Le Foll
Aug 15, 2021·Nutrition Reviews·Jenny G TurcottOscar Arrieta
Dec 10, 2021·Journal of Cachexia, Sarcopenia and Muscle·Lucile SimonAdrian Slee