Efficacy and safety of aprotinin in cardiac surgery.

Orthopedics
Jerrold H Levy

Abstract

Cardiac surgery and cardiopulmonary bypass produces bleeding and the need for allogenic blood product transfusions in many patients. Blood conservation is important in the perioperative management of patients. Aprotinin, a serine protease inhibitor isolated from bovine lung, is a complex protease inhibitor that is an antifibrinolytic, inhibits contact activation, and decreases the inflammatory response to cardiopulmonary bypass. Aprotinin reduces blood loss and transfusion requirements in adult and pediatric patients undergoing cardiac surgery with cardiopulmonary bypass. Full-dose aprotinin significantly reduces postoperative blood loss and has been demonstrated in multiple prospective blinded studies to be safe and effective. One of the major adverse effects is anaphylaxis that occurs on re-exposure to aprotinin.

References

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Citations

Aug 30, 2011·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Craig P FischerDavid M Albala
Dec 12, 2012·Anesthesia and Analgesia·Lawrence Tim Goodnough, Aryeh Shander
Jun 30, 2009·Pharmacotherapy·Bradley A Boucher, Oren Traub
Oct 28, 2019·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Saurabh Kumar DasSumit Ray
May 11, 2010·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Hiroshi ShigetomiHiroshi Kobayashi
Mar 3, 2006·Expert Review of Cardiovascular Therapy·Neel R SodhaFrank W Sellke
Jun 13, 2006·Transfusion Medicine·R D SlightP S Mankad
Dec 22, 2006·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Walter FurstHeinz Redl

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Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.