Abstract
The current practice in Germany and Austria, and the safety and efficacy of botulinum toxin type A (BoNT-A; Dysport) in the treatment of patients with post-stroke arm spasticity (with no fixed upper-limb contractures), were assessed in this observational prospective non-interventional study. One treatment cycle was documented with assessments at baseline, approximately week 4 (optional), and approximately week 12. Pattern of spasticity, treatment goal, safety and efficacy were recorded. Overall response and goal achievement was rated on a 4-point scale ('no goal achievement', 'goal achievement', 'good goal achievement', 'best goal achievement'). In total, 409 patients were included and 99% assigned to one of five arm-spasticity patterns. Therapy goals included reduced muscle tone (92.6%), physiotherapy or occupational therapy support (63.8%), increased range of motion (61.8%), pain reduction (58.9%), facilitation of care or hygiene (55.7%), and functional improvement (17.0%). Goals were achieved in 84% of patients. The following factors had the most potential as predictors of treatment outcome: pre-treatment; time since onset of spasticity; pattern of arm spasticity. Mean Dysport dose was 728 U and an inverse dose-response rela...Continue Reading
References
Mar 7, 1992·BMJ : British Medical Journal·D T WadeC P Warlow
Apr 23, 1999·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·R PellizzariC Montecucco
Nov 25, 2000·British Medical Bulletin·B B Bhakta
Jan 11, 2002·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A M BakheitL Coxon
Oct 27, 2004·Neurology·E MontanéJ R Laporte
May 7, 2008·Neurology·D M SimpsonUNKNOWN Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology
May 27, 2008·Brain Research Bulletin·J Málly, E Dinya
Feb 7, 2009·Journal of Rehabilitation Medicine·Jörg WisselNiko Tieranta
Sep 4, 2009·Neurological Research·B MohammadiK Kollewe
Feb 16, 2010·International Journal of Rehabilitation Research. Internationale Zeitschrift Für Rehabilitationsforschung. Revue Internationale De Recherches De Réadaptation·Abdel Magid BakheitJorg Wissel
May 14, 2010·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Andy Pickett
Jun 3, 2010·Health Technology Assessment : HTA·L ShawUNKNOWN BoTULS investigators
May 5, 2012·International Journal of Rehabilitation Research. Internationale Zeitschrift Für Rehabilitationsforschung. Revue Internationale De Recherches De Réadaptation·Harald HefterJörg Wissel
Citations
Apr 10, 2015·Toxins·Klemens FheodoroffLynne Turner-Stokes
Sep 1, 2015·Lancet Neurology·Jean-Michel GraciesUNKNOWN International AbobotulinumtoxinA Adult Upper Limb Spasticity Study Group
Jun 19, 2016·PM & R : the Journal of Injury, Function, and Rehabilitation·Andrew K TreisterEric Y Chang
Sep 7, 2016·Journal of Anatomy·F GenetB Parratte
Jan 26, 2017·Clinical Rehabilitation·Kyung Hee DoDon-Kyu Kim
Jun 8, 2017·Muscle & Nerve·Jean-Michel GraciesUNKNOWN International AbobotulinumtoxinA Adult Upper Limb Spasticity Study Group
Jun 22, 2017·PM & R : the Journal of Injury, Function, and Rehabilitation·Michael W O'DellJean Michel Gracies
Mar 29, 2018·Maxillofacial Plastic and Reconstructive Surgery·Hyun SeokJanghoon Ahn
Mar 31, 2018·Toxins·Giancarlo IanieriMarisa Megna
Mar 19, 2020·Frontiers in Neurology·Jörg WisselManuel Koch
Jul 25, 2020·Journal of Neuroengineering and Rehabilitation·S ChandraN L Suresh