Efficacy and Safety of Bromocriptine-QR in Type 2 Diabetes: A Systematic Review and Meta-Analysis

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme
W LiangH Pan

Abstract

Bromocriptine-QR (quick release) is a novel treatment for type 2 diabetes. The objective of this study is to assess the efficacy and safety of bromocriptine-QR in adults with type 2 diabetes mellitus based on randomized controlled trials published in peer-reviewed journals or as abstracts. We performed a comprehensive literature search of MEDLINE, Pubmed, Web of Science, EMBASE, and the Cochrane Library up to May 2015. Randomized controlled trials of bromocriptine-QR therapy in type 2 diabetes mellitus were eligible. Two reviewers independently assessed the eligibility of trials based on predefined inclusion criteria. Information was collected concerning basic study data, patient characteristics, efficacy and safety outcomes, and methodological quality. Bromocriptine-QR add-on therapy lowered hemoglobin A1c compared with placebo (weighted mean difference, - 6.52 mmol/mol; 95% CI, - 8.07 to - 4.97 mmol/mol). Bromocriptine-QR exhibited an increase in achieving an HbA1c level ≤ 53 mmol/mol (≤ 7.0%) (32.0 vs. 9.5%; odds ratio, 4.57; 95% CI, 2.42-8.62). Fasting plasma glucose was reduced with bromocriptine-QR compared with placebo (weighted mean difference,-1.04 mmol/l; 95% CI,-1.49 to-0.59 mmol/l). Moreover, bromocriptine-QR had ne...Continue Reading

Citations

Jan 10, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Felicitas Lopez VicchiDamasia Becu-Villalobos
Jun 25, 2016·Nature Reviews. Endocrinology·Abd A TahraniClifford J Bailey
Mar 1, 2016·Expert Review of Endocrinology & Metabolism·Philip Raskin, Anthony H Cincotta
Dec 12, 2018·Nature Reviews. Endocrinology·Dirk Jan StenversAndries Kalsbeek
Jul 2, 2021·Journal of Clinical & Translational Endocrinology·Lukas AndereggenEmanuel Christ

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