Efficacy and safety of budesonide/formoterol single inhaler therapy versus a higher dose of budesonide in moderate to severe asthma

Current Medical Research and Opinion
R ScicchitanoC Hultquist

Abstract

This study evaluated the efficacy and safety of a novel asthma management strategy--budesonide/formoterol for both maintenance and symptom relief (Symbicort Single Inhaler Therapy)--compared with a higher maintenance dose of budesonide in patients with moderate to severe asthma. This was a 12-month, randomised, double-blind, parallel-group study. Symptomatic patients with asthma (n = 1890; mean age 43 years [range 11 years-80 years], mean baseline forced expiratory volume in 1 s [FEV(1)] 70% of predicted, mean inhaled corticosteroid [ICS] dose 746 microg/day) received either budesonide (160 microg, 2 inhalations twice daily) plus terbutaline 0.4 mg as needed or a daily maintenance dose of budesonide/formoterol (160/4.5 microg, 2 inhalations once daily) with additional inhalations of budesonide/formoterol 160/4.5 microg as needed. Time to first severe exacerbation (hospitalisation/emergency room [ER] treatment or systemic steroids due to asthma worsening or a fall in morning peak expiratory flow [PEF] to < or = 70% of baseline on 2 consecutive days) was the primary outcome variable. A total of 1890 patients were randomised, of whom 1563 (83%) had severe asthma. The time to first severe exacerbation was prolonged by budesonide/fo...Continue Reading

References

May 1, 1992·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P G GibsonF E Hargreave
Oct 1, 1982·The Journal of Allergy and Clinical Immunology·J H ToogoodS A Johansson
Jan 20, 1999·Respiratory Medicine·N RingdalR Pauwels
Aug 3, 1999·American Journal of Respiratory and Critical Care Medicine·A E TattersfieldA Ullman
Dec 22, 1999·The European Respiratory Journal·J van der PalenE R Seydel
Jan 12, 2001·The European Respiratory Journal·K F RabeW C Maier
Aug 21, 2001·The European Respiratory Journal·P Bergquist, G K Crompton
May 17, 2003·Pulmonary Pharmacology & Therapeutics·Jaro AnkerstEva Weibull
Nov 19, 2003·The European Respiratory Journal·R A PauwelsUNKNOWN RELIEF Study investigators
Dec 18, 2003·Canadian Respiratory Journal : Journal of the Canadian Thoracic Society·J Mark FitzGeraldUNKNOWN Canadian Investigators
May 5, 2004·Pulmonary Pharmacology & Therapeutics·Hanneke J van der WoudeRené Aalbers

❮ Previous
Next ❯

Citations

Oct 15, 2010·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Geoff K Frampton, Jonathan Shepherd
Aug 29, 2006·Lancet·Paul M O'Byrne, Krishnan Parameswaran
Mar 29, 2007·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·Israel AmiravAnthony S Luder
Apr 24, 2009·Current Opinion in Pediatrics·Craig M Schramm, Christopher L Carroll
May 12, 2010·International Journal of Clinical Practice·S J EdwardsT Harrison
Oct 27, 2004·American Journal of Respiratory and Critical Care Medicine·Paul M O'ByrneEric D Bateman
Jan 12, 2008·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Milind P SovaniTimothy W Harrison
May 27, 2008·Naunyn-Schmiedeberg's Archives of Pharmacology·Dirkje S PostmaNick H T ten Hacken
Sep 22, 2009·Advances in Therapy·Lucas M A GoossensMaureen P M H Rutten-van Mölken
Jul 30, 2014·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Chitra DinakarDana Wallace
Sep 4, 2014·Current Allergy and Asthma Reports·Chitra Dinakar, Jay M Portnoy
Sep 4, 2009·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Kang-Cheng SuDiahn-Warng Perng
Sep 29, 2011·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Santiago QuirceMargarita Capel
Sep 11, 2014·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Marci ClarkLoretta Jacques
Dec 1, 2005·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Jaro Ankerst
Oct 1, 2008·Expert Review of Respiratory Medicine·Christina Lee, Jonathan Corren
Oct 7, 2010·Expert Review of Respiratory Medicine·David HodgsonTim Harrison
Jul 22, 2009·Expert Opinion on Drug Metabolism & Toxicology·Dennis KimRichard Lockey
Jun 29, 2007·Current Medical Research and Opinion·Steven J EdwardsDermot P Ryan
May 8, 2015·Lung India : Official Organ of Indian Chest Society·Ritesh AgarwalSubhash Varma
Jul 9, 2005·Chest·Mina GagaStavros Konstantopoulos
Feb 16, 2006·Chest·Krishnan Parameswaran
Mar 13, 2012·Revue des maladies respiratoires·S Grassin-Delyle, P-O Girodet
Mar 17, 2010·The Journal of Allergy and Clinical Immunology·Kenneth R Chapman
Feb 16, 2010·The Journal of Allergy and Clinical Immunology·Eric D BatemanPaul M O'Byrne

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.