Efficacy and Safety of Bushenjiangya-Optimized Granule for Left Ventricular Diastolic Dysfunction in Hypertensive Patients: A Double-Blind, Randomized, Placebo-Controlled Trial

Evidence-based Complementary and Alternative Medicine : ECAM
Qun GaoQian Lin

Abstract

The study aimed to evaluate the efficacy and safety of Bushenjiangya-optimized (BSJYO) granule on left ventricular diastolic dysfunction (LVDD) in hypertensive (HTN) patients. 120 patients diagnosed with HTN plus LVDD were randomly assigned to the BSJYO granule group and placebo group, and all patients received basal western medicine (WM) treatment. After eight weeks of treatment, we evaluated echocardiography, traditional Chinese medicine (TCM) syndromes, 24-hour ambulatory blood pressure, liver and kidney functions, and adverse events. Major adverse cardiovascular events (MACEs) were collected at 6-month follow-up. Compared with pretreatment, E/Ea (Doppler-derived index of filling pressure and worsening LVDD) significantly decreased significantly after 8 weeks of treatment in the BSJYO granule plus basal WM group (10.52 ± 1.87 vs. 9.49 ± 1.49, P < 0.01), alongside reductions in significantly effective response (SER), effective response (ER), and total effective response (TER = SER + ER) in TCM symptom scores (21.59% vs. 71.70%, P < 0.01). There were no differences between treatment groups in kidney and liver function, early adverse events, or MACE. BSJYO granule plus basal WM is an effective and safe therapy for HTN patients ...Continue Reading

References

Jan 9, 2003·JAMA : the Journal of the American Medical Association·Margaret M RedfieldRichard J Rodeheffer
Mar 12, 2003·Circulation·J Malcolm O ArnoldUNKNOWN HOPE Investigators
May 3, 2006·Circulation·Barry R DavisUNKNOWN Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial Collaborative Research Group
May 12, 2009·The Medical Clinics of North America·Anil Verma, Scott D Solomon
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Jun 29, 2011·Archives of Internal Medicine·Carmel M HalleyWael A Jaber
Sep 1, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Sinai LiQian Lin

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