Abstract
Acute myeloid leukemia (AML) is the most common malignant tumor of the hematopoietic system, which seriously threatens the lives of patients. Most AML patients have acute onset, severe condition, and poor prognosis. The present study aimed to comprehensively evaluate the effectiveness and safety of chemotherapy combined with different doses of interleukin-2 (IL-2) maintenance treatments in AML by Bayesian network meta-analysis (NMA). From its inception until October 2021, we will search PubMed, Cochrane Library, CNKI, Embase, and other databases to comprehensively collect randomized controlled trials (RCTs) of chemotherapy combined with different doses of IL-2 maintenance therapies for AML. Two independent researchers will complete the literature screening and data extraction according to the inclusion and exclusion criteria, and then independently conduct a bias risk assessment of all the evidence. Bayesian NMA was used to evaluate all the evidence comprehensively. Use STATA16.0 and WinBUGS1.4.3 software to process and analyze all data, and classify the quality of evidence in NMA according to grading of recommendations assessment, development, and evaluation . The study will evaluate the efficacy and safety of chemotherapy com...Continue Reading
References
Dec 5, 1985·The New England Journal of Medicine·S A RosenbergJ T Vetto
Jul 2, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Maria R BaerRichard A Larson
Dec 24, 2008·American Journal of Hematology·Benjamin GesundheitReuven Or
Jan 6, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Cecile PautasSylvie Castaigne
Mar 10, 2010·Statistics in Medicine·S DiasA E Ades
Aug 7, 2010·Journal of Clinical Epidemiology·Georgia SalantiJohn P A Ioannidis
Feb 15, 2013·Experimental and Therapeutic Medicine·Sheng LuoShenmeng Gao
Jan 3, 2014·Cancer·Jonathan E KolitzUNKNOWN Alliance for Clinical Trials in Oncology
Sep 26, 2014·BMJ : British Medical Journal·Milo A PuhanUNKNOWN GRADE Working Group
Oct 17, 2014·Journal of Biopharmaceutical Statistics·Divan Aristo Burger, Robert Schall
Jan 4, 2015·BMJ : British Medical Journal·Larissa ShamseerUNKNOWN PRISMA-P Group
Mar 26, 2015·European Journal of Pediatrics·R A AmmannA Simon
Sep 12, 2015·Biometrical Journal. Biometrische Zeitschrift·Rafael Sauter, Leonhard Held
Oct 4, 2015·Leukemia Research·Qi QuDepei Wu
Nov 11, 2016·JAMA Oncology·Anna B HalpernGary H Lyman
Nov 30, 2016·Blood·Hartmut DöhnerClara D Bloomfield
Jul 12, 2017·Journal of Translational Medicine·Meghali GoswamiChristopher S Hourigan
Jun 4, 2018·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Hideaki KatoUNKNOWN Japan Adult Leukemia Study Group
Oct 26, 2018·Research Synthesis Methods·Isabelle Albert, David Makowski