Efficacy and Safety of Complete Mesocolic Excision in Patients With Colon Cancer: Three-year Results From a Prospective, Nonrandomized, Double-blind, Controlled Trial.

Annals of Surgery
Zhi-dong GaoYing-jiang Ye

Abstract

The aim of the study was to evaluate the oncological outcomes of complete mesocolic excision (CME) in colon cancer patients. CME is considered a standard procedure for colon cancer patients. However, previous evidence regarding the effect of CME on prognosis has fundamental limitations that prevent it from being fully accepted. Patients who underwent radical resection for colon cancer were enrolled between November 2012 and March 2016. According to the principles of CME, patients were stratified into 2 groups based on intraoperative surgical fields and specimen photographs. The primary outcome was local recurrence-free survival (LRFS). The clinicopathological data and follow-up information were collected and recorded. The final follow-up date was April 2016. The trial was registered in ClinicalTrials.gov (identifier: NCT01724775). There were 220 patients in the CME group and 110 patients in the noncomplete mesocolic excision (NCME) group. Baseline characteristics were well balanced. Compared with NCME, CME was associated with a greater number of total lymph nodes (24 vs 20, P = 0.002). Postoperative complications did not differ between the 2 groups. CME had a positive effect on LRFS compared with NCME (100.0% vs 90.2%, log-rank...Continue Reading

Associated Clinical Trials

References

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Feb 26, 2014·Annals of Surgical Oncology·Hirotoshi KobayashiKenichi Sugihara
Jan 19, 2016·The British Journal of Surgery·C A BertelsenUNKNOWN on the behalf of the Copenhagen Complete Mesocolic Excision Study COMES Group and the Danish Colorectal Cancer Group DCCG
Mar 30, 2017·International Journal of Clinical Oncology·Toshiaki WatanabeUNKNOWN Japanese Society for Cancer of the Colon and Rectum
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Citations

Feb 27, 2019·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Tahir K YozgatliDursun Bugra
Feb 7, 2020·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Juha Ka RinneJyrki Ao Kössi
Jun 4, 2020·Annals of Gastroenterological Surgery·Hyunmi ParkSeon-Hahn Kim
Sep 22, 2020·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Zachariah Gene Wing OwChoon Seng Chong
May 3, 2021·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Jasmine CraneAdam T Stearns
Jul 28, 2021·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Claus Anders BertelsenJakob Kleif
Aug 5, 2021·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Burak KutluMehmet Ayhan Kuzu

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