Efficacy and Safety of Cross-Linked Carboxymethylcellulose Filler for Rejuvenation of the Lower Face: A 6-Month Prospective Open-Label Study

Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]
Maria Cristina DʼAloisoBruno Azzena

Abstract

Cross-linked carboxymethylcellulose (CMC) filler is a biosynthetic filler with very low antigenic risk. To assess the efficacy and safety of CMC filler in the rejuvenation of the lower face. Two hundred eighty-seven procedures were performed in 174 patients: 115 nasolabial folds, 86 marionette lines, 29 bar codes, 14 cheek rhytides, and 43 lip rejuvenations. Results were evaluated at 3 (T1) and 6 months (T2) with photographic evaluation, Global Aesthetic Improvement Scale (GAIS), Modified Fitzpatrick Wrinkle Scale (MFWS) for nasolabial folds, Marionette Lines Grading Scale (MLGS), and Medicis Lip Fullness Scale (LFS). GAIS was ≥2 in >91.05% of patients both in T1 and T2. MFWS score significantly improved at T1 (86.9% class ≤1, p < .001) and T2 (82.6% class ≤1, p < .001); in all patients in T1 and T2, median amelioration of MLGS was 2 ± 1 and there was a significant amelioration of at least 1 grade in LSF in both upper and lower lips. The use of CMC filler resulted in a significant and satisfactory amelioration of lower face aging signs with very low incidence of adverse events. Therefore, it should be considered a valid alternative to cross-linked hyaluronic acid fillers.

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Citations

May 7, 2020·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·Benrita JitareeTanvaa Tansatit

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