EFFICACY AND SAFETY OF DEXAMETHASONE INTRAVITREAL IMPLANT FOR PERSISTENT UVEITIC CYSTOID MACULAR EDEMA

Retina
Rahul N Khurana, Travis C Porco

Abstract

To investigate dexamethasone intravitreal implant (DEX Implant 0.7 mg, Ozurdex; Allergan, Inc, Irvine, CA) as a treatment for persistent cystoid macular edema (CME) secondary to uveitis. Treatment and outcomes data were collected retrospectively for 18 eyes from 13 consecutive patients treated with the DEX Implant for persistent, noninfectious uveitic CME. Outcome measures included the cumulative incidence of resolution of CME, visual acuity, central retinal thickness (measured by spectral domain optical coherence tomography), and vitreous haze score. After a single DEX Implant, there was no detectable CME in 89% and 72% of eyes at 1 month and 3 months, respectively. The median time to recurrence of CME (±standard error) was 201 ± 62 days. The percentage of eyes with no recurrence of CME was 35% at 6 months and 30% at 12 months. At 3 months, there was a significant improvement from baseline in mean visual acuity (+2.1 lines, P < 0.01). Eyes with an epiretinal membrane at baseline had shorter time to recurrence of CME and smaller improvements in visual acuity and central retinal thickness than eyes without an epiretinal membrane. At least 1 episode of intraocular pressure >25 mmHg occurred within the first 3 months in 11% (2 of ...Continue Reading

References

Oct 1, 1990·International Ophthalmology·R B Nussenblatt
Feb 25, 2000·BMJ : British Medical Journal·P J McCluskeyS Lightman
Jul 11, 2003·Ocular Immunology and Inflammation·Narciss Okhravi, Susan Lightman
Oct 1, 2005·American Journal of Ophthalmology·Douglas A JabsUNKNOWN Standardization of Uveitis Nomenclature (SUN) Working Group
Mar 14, 2007·Archives of Ophthalmology·Baruch D KuppermannUNKNOWN Dexamethasone DDS Phase II Study Group
Mar 10, 2009·American Journal of Ophthalmology·George A WilliamsUNKNOWN Dexamethasone DDS Phase II Study Group
Jan 12, 2011·Archives of Ophthalmology·Careen LowderUNKNOWN Ozurdex HURON Study Group
Jun 10, 2011·American Journal of Ophthalmology·Henry A LederJennifer E Thorne
Aug 3, 2011·Progress in Retinal and Eye Research·Marc D de SmetSue Lightman
Apr 26, 2012·Ocular Immunology and Inflammation·Simon R J TaylorJohn H Kempen
Dec 14, 2012·Expert Review of Clinical Pharmacology·Michael R Robinson, Scott M Whitcup
Jun 29, 2013·Clinical Ophthalmology·Rushmia KarimSamantha Fraser-Bell
Feb 4, 2014·American Journal of Ophthalmology·Brian LehpamerDouglas A Jabs

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Citations

Sep 15, 2015·Current Opinion in Ophthalmology·Claudia Fabiani, Jorge L Alió
Nov 26, 2015·Clinics in Chest Medicine·Sirichai Pasadhika, James T Rosenbaum
Aug 1, 2015·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Ruti SellaMichal Kramer
Aug 31, 2016·International Ophthalmology Clinics·Sarah A LoganPetros E Carvounis
Apr 28, 2017·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Ariane FrèreFrançois Willermain
May 31, 2017·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Claudia FabianiLuca Cantarini
Jan 31, 2018·International Ophthalmology·Murat HasanreisogluSengul Ozdek
Aug 15, 2019·Clinical & Experimental Ophthalmology·Matthew McCartneySophia Zagora
Jun 18, 2017·Current Opinion in Pulmonary Medicine·Sung J YangJames T Rosenbaum
Feb 3, 2018·Ocular Immunology and Inflammation·Dhanashree RatraJyotirmay Biswas
Sep 5, 2019·AAPS PharmSciTech·Kawther Khalid AhmedAliasger K Salem
Jul 4, 2020·Retina·Thibaud MathisLaurent Kodjikian
Jun 3, 2020·Journal of Medicinal Chemistry·Kuei-Ju ChengJing-Ping Liou

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