Efficacy and safety of diosmectite in acute childhood diarrhoea: a meta-analysis

Archives of Disease in Childhood
Rashmi Ranjan DasSushree Samiksha Naik

Abstract

We evaluated the role of diosmectite as an add-on treatment to the 'recommended treatment' of acute diarrhoea in children. We searched all published literature through the major databases: Medline via Ovid, PubMed, CENTRAL, Embase and Google Scholar till May 2014. Randomised clinical trials comparing diosmectite versus placebo were included (PROSPERO registration: CRD42014013783). The primary outcome measures were duration of acute diarrhoea (h), and day-to-day cure rates (%). The secondary outcome measures were stool output (volume), stool output (frequency) and adverse events. Of 384 citations retrieved, a total of 13 randomised clinical trials (2164 children, 1-60 months old) were included in the meta-analysis. A dose of 3-6 grams per day of diosmectite was given for a duration from 3 days until recovery. Compared with placebo, diosmectite significantly decreased the duration of acute diarrhoea (mean difference, -23.39; 95% CI -28.77 to -18.01), and increased the cure rate (%) at day 5 (OR, 4.44; 95% CI 1.66 to 11.84), without any increases in the risk of adverse events. Diosmectite was effective in all types of acute childhood diarrhoea except dysentery. Because, most of the trials were open-label, and there was a high poss...Continue Reading

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Citations

Apr 26, 2018·The Cochrane Database of Systematic Reviews·Giordano Pérez-GaxiolaVíctor M Pérez-Pico
Nov 10, 2017·Nature Reviews. Disease Primers·Sue E CrawfordMary K Estes
Sep 6, 2018·Food & Function·Monique Santos do CarmoValério Monteiro-Neto
Nov 18, 2015·Intestinal research·Kwang Jae Lee
Mar 24, 2017·Journal of Tropical Medicine·Samarendra MahapatroRashmi Ranjan Das
Feb 23, 2019·Healthcare·Fenella CorrickHelen Sammons
Jan 30, 2020·Current Infectious Disease Reports·Ivan D FlorezClaudia P Beltrán-Arroyave
May 30, 2019·BMJ Open Gastroenterology·Carol Angela HowellRamesh Arasaradnam

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