Efficacy and Safety of Direct Acting Antiviral Therapy for Chronic Hepatitis C in Thalassemic Children

Journal of Pediatric Hematology/oncology
Shivadatta PadhiSandeep Nijhawan

Abstract

There is limited data on the efficacy and safety of directly acting antiviral therapy (DAA) for chronic hepatitis C in pediatric population. The aim was to assess the efficacy and safety of DAA in chronic hepatitis C β-thalassemic major pediatric patients. Prospective study was conducted from September 2015 to January 2017. All β-thalassemic major chronic hepatitis C pediatric patients with age between 5 and 14 years were included in this study. Data related to demography, laboratory parameters, hepatitis C viral load, genotype and outcome of antiviral therapy was analyzed. DAA was planned according to EASL guidelines 2015 for chronic hepatitis C therapy in adults. Fourteen β-thalassemic major patients (median age was 9.5 y, 12 male) were studied. All patients were of genotype 3, received DAA (sofosbuvir 400 mg+daclatasvir 80 mg) for 12 weeks. The median viral load was 2.5×10 IU/mL. End of treatment response and sustained virological response at 12 weeks was achieved in all the patients. Serum alanine aminotransferase, aspartate aminotransferase, ferritin, and albumin significantly reduced after DAA. DAA in adult dosage are safe and effective for treatment of chronic hepatitis C (genotype 3) in pediatric β-thalassemic major pop...Continue Reading

References

Jan 23, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Paloma JaraFlavia Bortolotti
Aug 2, 2008·Haematologica·Emanuele Angelucci, Federica Pilo
Jul 30, 2009·Journal of Viral Hepatitis·S-M Alavian, S-V Tabatabaei
May 6, 2010·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Ajit SoodSandeep Puri
Jun 17, 2010·Blood·Vito Di MarcoUNKNOWN Italian Association for the Study of the Liver
Jan 19, 2012·World Journal of Gastroenterology : WJG·Stefan Wirth
Mar 3, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Maureen M JonasChristopher Duggan
Apr 24, 2013·The New England Journal of Medicine·Eric LawitzEdward J Gane
May 6, 2014·The New England Journal of Medicine·Stefan ZeuzemUNKNOWN VALENCE Investigators
Jan 24, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·David R NelsonUNKNOWN ALLY-3 Study Team
Apr 26, 2015·Journal of Hepatology·UNKNOWN European Association for Study of Liver
Jun 19, 2015·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Shrivastava ManishaDwivedi Rashmi
Jun 26, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·UNKNOWN AASLD/IDSA HCV Guidance Panel
Mar 2, 2016·The Pediatric Infectious Disease Journal·Björn FischlerMikael Sundin
Sep 27, 2016·Journal of Hepatology·UNKNOWN European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu
Dec 21, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·William F BalistreriKathleen Schwarz
Mar 4, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Christophe HézodeUNKNOWN C-EDGE IBLD Study Investigators
May 26, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Stefan WirthKathleen B Schwarz

❮ Previous
Next ❯

Citations

Jun 12, 2020·Seminars in Liver Disease·Manal H El-Sayed, Giuseppe Indolfi
Jun 8, 2021·World Journal of Gastroenterology : WJG·Emanuele NicastroLorenzo D'Antiga

❮ Previous
Next ❯

Methods Mentioned

BETA
electrophoresis
ELISA
biopsy

Software Mentioned

statistical package for social sciences ( SPSS )

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.