Abstract
There is limited data on the efficacy and safety of directly acting antiviral therapy (DAA) for chronic hepatitis C in pediatric population. The aim was to assess the efficacy and safety of DAA in chronic hepatitis C β-thalassemic major pediatric patients. Prospective study was conducted from September 2015 to January 2017. All β-thalassemic major chronic hepatitis C pediatric patients with age between 5 and 14 years were included in this study. Data related to demography, laboratory parameters, hepatitis C viral load, genotype and outcome of antiviral therapy was analyzed. DAA was planned according to EASL guidelines 2015 for chronic hepatitis C therapy in adults. Fourteen β-thalassemic major patients (median age was 9.5 y, 12 male) were studied. All patients were of genotype 3, received DAA (sofosbuvir 400 mg+daclatasvir 80 mg) for 12 weeks. The median viral load was 2.5×10 IU/mL. End of treatment response and sustained virological response at 12 weeks was achieved in all the patients. Serum alanine aminotransferase, aspartate aminotransferase, ferritin, and albumin significantly reduced after DAA. DAA in adult dosage are safe and effective for treatment of chronic hepatitis C (genotype 3) in pediatric β-thalassemic major pop...Continue Reading
References
Jan 23, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Paloma JaraFlavia Bortolotti
Jun 17, 2008·Haematologica·Vito Di MarcoAntonio Craxì
Aug 2, 2008·Haematologica·Emanuele Angelucci, Federica Pilo
Jul 30, 2009·Journal of Viral Hepatitis·S-M Alavian, S-V Tabatabaei
May 6, 2010·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Ajit SoodSandeep Puri
Jun 17, 2010·Blood·Vito Di MarcoUNKNOWN Italian Association for the Study of the Liver
Jan 19, 2012·World Journal of Gastroenterology : WJG·Stefan Wirth
Mar 3, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Maureen M JonasChristopher Duggan
Mar 29, 2012·North American Journal of Medical Sciences·Anupam Prakash, Ramesh Aggarwal
Sep 19, 2012·Asian Journal of Transfusion Science·Roopam JainN Choudhury
Apr 24, 2013·The New England Journal of Medicine·Eric LawitzEdward J Gane
Jan 21, 2014·Indian Journal of Pathology & Microbiology·Raj Nath MakrooAntony Minimol
May 6, 2014·The New England Journal of Medicine·Stefan ZeuzemUNKNOWN VALENCE Investigators
Jan 24, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·David R NelsonUNKNOWN ALLY-3 Study Team
Apr 26, 2015·Journal of Hepatology·UNKNOWN European Association for Study of Liver
Jun 19, 2015·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Shrivastava ManishaDwivedi Rashmi
Jun 26, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·UNKNOWN AASLD/IDSA HCV Guidance Panel
Aug 8, 2015·Gastroenterology·Graham R FosterUNKNOWN BOSON Study Group
Jan 12, 2016·Bone Marrow Transplantation·P ThomasM H Dallas
Mar 2, 2016·The Pediatric Infectious Disease Journal·Björn FischlerMikael Sundin
Sep 27, 2016·Journal of Hepatology·UNKNOWN European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu
Dec 21, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·William F BalistreriKathleen Schwarz
Mar 4, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Christophe HézodeUNKNOWN C-EDGE IBLD Study Investigators
May 26, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Stefan WirthKathleen B Schwarz
Citations
Jun 12, 2020·Seminars in Liver Disease·Manal H El-Sayed, Giuseppe Indolfi
Aug 19, 2020·Alimentary Pharmacology & Therapeutics·Giuseppe IndolfiErsilia Lucenteforte
Jun 8, 2021·World Journal of Gastroenterology : WJG·Emanuele NicastroLorenzo D'Antiga
Jun 26, 2021·Frontiers in Medicine·Zuqiang FuMing Yue