Abstract
In acute portal vein thrombosis (APVT) unrelated to cirrhosis, anticoagulant therapy is classically started with low molecular weight heparin or vitamin K antagonists. New direct-acting oral anticoagulants (DOACs) are used in the treatment of venous thrombosis outside the splanchnic vascular bed, but not in the latter. We report a young female with APVT occurring in a non-cirrhotic liver linked to heterozygosity of factor V-Leiden and prothrombin G20210A gene mutations. Rivaroxaban was started, with total recanalization of the left and partial recanalization of the right portal vein branches, without complications. New DOACs do not need daily subcutaneous injections nor routinely blood coagulation control tests, making its use attractive, eventually increasing patient's compliance. If proved to be safe and effective in the future studies, its use may be extended to PVT treatment. This case shows that rivaroxaban was safe, not only prevented the extension of thrombosis in the portal tract, but also resolved PVT, at least partially.
Citations
Mar 27, 2018·Expert Review of Anticancer Therapy·Eran ZimranMarina Kremyanskaya
Dec 6, 2017·Vascular Medicine·Nicoletta Riva, Walter Ageno
Sep 20, 2018·American Journal of Hematology·Chiara Dal ZottoLucia De Franceschi
Nov 13, 2018·British Journal of Hospital Medicine·Jecko Thachil
Apr 6, 2019·The Annals of Pharmacotherapy·Taylor D SteuberSarah A Nisly
Sep 24, 2019·Hospital Practice·Graham R HaleTaki Galanis
Nov 10, 2018·Endoscopy International Open·Haoxiong ZhouYunwei Guo
Jul 6, 2018·International Journal of Hepatology·P PriyankaG J Reynolds
Jan 10, 2020·Blood·Maria AbbattistaIda Martinelli
Nov 22, 2020·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Patrick G NorthupDominique C Valla
Feb 23, 2021·Der Gastroenterologe : Zeitschrift Für Gastroenterologie Und Hepatologie·C SteibM Seidensticker
Mar 8, 2021·La Revue de médecine interne·A GuyotT Degand
Jul 5, 2021·Acta Gastro-enterologica Belgica·A Galante, A De Gottardi
Aug 10, 2021·Curēus·Sachin GuptaSorab Gupta
Aug 17, 2021·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Jin Hean KohYu Jun Wong