Efficacy and Safety of Edoxaban in Nonvalvular Atrial Fibrillation: A Meta-analysis of Randomized Controlled Trials

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
Junyu ChenLichun Wang

Abstract

Edoxaban is a potential alternative to warfarin for preventing thromboembolism in atrial fibrillation. However, the efficacy and safety, and the optimal regimen of edoxaban are still controversial. This study compared the efficacy and safety of edoxaban and warfarin in nonvalvular atrial fibrillation, and the effects of different edoxaban dosages. A systematic search for randomized controlled trials comparing edoxaban with warfarin in nonvalvular atrial fibrillation was conducted using PubMed, EMBASE, and the Cochrane Library databases. The main measures and outcomes included efficacy end points (thromboembolic events and all-cause mortality) and safety end points (all bleeding events, major bleeding events, clinically relevant nonmajor bleeding, and minor bleeding). Four studies including 23,001 patients were included in the meta-analysis. Edoxaban was noninferior to warfarin for preventing stroke and systemic embolism (risk ratio [RR] = 1.00; 95% confidence interval [CI], .88-1.13; Z = .01; P = .99). In safety analyses, edoxaban was superior to warfarin in terms of major bleeding, clinically relevant nonmajor bleeding, and minor bleeding (all P <.00001). In terms of optimal dosing, 30 mg/day edoxaban had a significantly lower...Continue Reading

References

Jun 13, 2001·JAMA : the Journal of the American Medical Association·B F GageM J Radford
May 21, 2003·Annals of Internal Medicine·Robert G HartUNKNOWN Stroke Prevention in Atrial Fibrillation Investigators
Apr 22, 2005·Journal of Thrombosis and Haemostasis : JTH·S SchulmanUNKNOWN Subcommittee on Control of Anticoagulation of the Scientific and Standardization Committee of the International Society on T
Sep 5, 2009·Journal of the American College of Cardiology·Daniela PoliDomenico Prisco
Jun 6, 2012·Circulation Journal : Official Journal of the Japanese Circulation Society·Takeshi YamashitaSatoshi Ogawa
Jul 6, 2012·Journal of Thrombosis and Thrombolysis·Mirjana K KovacDragica P Radojkovic
Apr 30, 2013·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Hein HeidbuchelUNKNOWN European Heart Rhythm Association
Jul 23, 2013·Vascular Pharmacology·Giulia Renda, Raffaele De Caterina
Aug 21, 2013·Best Practice & Research. Clinical Haematology·Raji Shameem, Jack Ansell
Sep 3, 2013·The New England Journal of Medicine·Harry R BüllerPhil Wells
Nov 21, 2013·The New England Journal of Medicine·Robert P GiuglianoUNKNOWN ENGAGE AF-TIMI 48 Investigators
Mar 22, 2014·Expert Review of Cardiovascular Therapy·Gregory Yh Lip
May 3, 2014·Stroke; a Journal of Cerebral Circulation·Walter N KernanUNKNOWN American Heart Association Stroke Council, Council on Cardiovascular and Stroke Nursing, Council on Clinical Cardiology, and

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