Efficacy and Safety of Endoscopic Intralesional Triamcinolone Injection for Benign Esophageal Strictures

Gastroenterology Research and Practice
Ya-Wu ZhangYou Cheng Zhang

Abstract

To evaluate the efficacy and safety of endoscopic intralesional triamcinolone injection (ITI) for benign esophageal strictures combined with endoscopic dilation (ED). Online databases including MEDLINE, EMBASE, the Cochrane Library, and Web of Science were comprehensively searched for prospective randomized control trials (RCTs) between 1966 and March 2018. A meta-analysis was conducted according to the methods recommended by the Cochrane Collaboration. Six RCTs consisting of 176 patients were selected. Meta-analysis results showed that additional ITI had a significant advantage in terms of stricture rate and required ED sessions. Surgery-related and non-surgery-related strictures showed similar results. Additional ITI was not associated with significantly increased risk of complications. Our meta-analysis showed that additional ITI therapy was supposed to be effective and safe for benign esophageal strictures as it reduced the stricture rate and required ED sessions. However, more RCTs are necessary to support these findings.

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Citations

Aug 29, 2019·Therapeutic Advances in Gastrointestinal Endoscopy·Simon M Everett
Jul 25, 2019·World Journal of Gastroenterology : WJG·Kai YangYing-Sheng Cheng
Nov 26, 2019·Journal of Pediatric Gastroenterology and Nutrition·Peter D NgoMichael A Manfredi
Mar 13, 2021·Dysphagia·Alessandro Fugazza, Alessandro Repici

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