Efficacy and safety of endoscopic submucosal dissection for superficial colorectal tumors more than 50 mm in diameter

Gastrointestinal Endoscopy
Yoshikazu HayashiHironori Yamamoto

Abstract

The feasibility of endoscopic submucosal dissection (ESD) for large superficial colorectal tumors is undefined. The aim of this study was to assess the outcomes for patients undergoing ESD of superficial colorectal tumors larger than 50 mm. A total of 472 patients who underwent ESD for superficial colorectal tumors from 2010 to 2014 were enrolled. We retrospectively reviewed their records. We compared patients with 20-mm to 50-mm lesions and those with lesions >50 mm regarding demographics, the ESD procedure, and histopathology. Among patients with lesions >50 mm, laterally spreading tumors nongranular and protruded types were uncommon. Histopathologically, deeply invasive (≥1000 μm) submucosal carcinomas were more frequent in lesions >50 mm (14% [10/70] vs 5% [20/402], P < .01). Technically, en bloc resection was successfully accomplished in 99% of patients (69/70). Although the total dissection time for lesions >50 mm was significantly longer than for lesions 20 mm to 50 mm (mean ± SD, 157 ± 114 minutes vs 68 ± 50 min; P < .01), dissection speed for lesions >50 mm was significantly faster than for lesions 20 mm to 50 mm (P < .01). There were no significant differences in en bloc R0 resection rate comparing both groups (>50 mm...Continue Reading

References

Oct 31, 2008·International Journal of Colorectal Disease·Kinichi HottaTakahisa Matsuda
Feb 2, 2013·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Shinji TanakaKazuaki Chayama
Jul 22, 2014·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Yoshikazu HayashiHironori Yamamoto
Feb 25, 2015·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Yoshikazu HayashiHironori Yamamoto
Mar 19, 2015·International Journal of Clinical Oncology·Toshiaki WatanabeUNKNOWN Japanese Society for Cancer of the Colon and Rectum

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Citations

Jun 28, 2016·Best Practice & Research. Clinical Gastroenterology·Matthew E Feurer, Peter V Draganov
Apr 21, 2017·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Kenichiro ImaiHiroyuki Ono
Jul 28, 2017·Minimally Invasive Therapy & Allied Technologies : MITAT : Official Journal of the Society for Minimally Invasive Therapy·Chihiro IwashitaHironori Yamamoto
Oct 26, 2018·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Michał SpychalskiAdam Dziki
May 13, 2020·Expert Review of Gastroenterology & Hepatology·Yuyong TanDeliang Liu
Aug 8, 2018·United European Gastroenterology Journal·João Santos-AntunesGuilherme Macedo
Oct 5, 2021·GE Portuguese Journal of Gastroenterology·João Santos-AntunesGuilherme Macedo

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