Efficacy and safety of entacapone in levodopa/carbidopa versus levodopa/benserazide treated Parkinson's disease patients with wearing-off

Journal of Neural Transmission
M KuoppamäkiWerner Poewe

Abstract

Entacapone is frequently used together with levodopa/carbidopa (LC) and levodopa/benserazide (LB) in the treatment of Parkinson's disease (PD) patients with wearing-off symptoms. It is generally assumed that the effects of entacapone are independent of the type of decarboxylase inhibitor used, but there is very little published data available on the efficacy of entacapone administered with LB versus LC. We have performed a pooled analysis of three randomized, double-blind, 6-month, phase III studies to compare the treatment effects of entacapone (compared to placebo) in PD patients receiving LC or LB. A total of 551 PD patients experiencing wearing-off were included in the analysis. 300 patients were on LB and 251 on LC at baseline. At 6 months, entacapone (compared to placebo) improved mean daily OFF-time in patients on LB and LC by 0.76 (p = 0.016) and 0.95 (p = 0.011) hours, respectively. The corresponding improvements in ON-time were 0.97 (p = 0.002) and 0.83 h (p = 0.022), respectively. The treatment effects of entacapone both in LB and LC users were statistically significant (p < 0.05) also in UPDRS II and III scores, except in UPDRS II scores in patients receiving LC (p = 0.20). None of the treatment effects of entacapon...Continue Reading

References

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Sep 1, 1995·British Journal of Clinical Pharmacology·J DingemanseP Van Brummelen
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Sep 5, 2014·Acta Neurologica Scandinavica·M KuoppamäkiK Kieburtz

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Citations

Jul 28, 2016·Journal of Enzyme Inhibition and Medicinal Chemistry·Joanna MatysiakDagmara Kłopotowska
Sep 5, 2018·Acta Neurologica Scandinavica·Ilias ThomasDag Nyholm
Jan 24, 2019·Journal of Gambling Studies·Cristina ScavoneAnnalisa Capuano
Jul 1, 2016·Reviews in the Neurosciences·Joseph R PhillipsAhmed A Moustafa
Apr 3, 2019·Drugs & Aging·Martin KlietzGünter U Höglinger
Jul 21, 2020·Drug Discovery Today·Tiago Barros SilvaPatrício Soares-da-Silva

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