Efficacy and safety of entecavir in patients with chronic hepatitis B and advanced hepatic fibrosis or cirrhosis

The American Journal of Gastroenterology
Eugene R SchiffRicardo Tamez

Abstract

The efficacy and safety of entecavir in patients with chronic hepatitis B and advanced liver fibrosis/cirrhosis was assessed from three large, randomized, multicenter, phase III studies. These studies enrolled patients (> or = 16 yr) with chronic hepatitis B, elevated alanine aminotransferase (ALT) levels, and compensated liver disease. Two trials enrolled nucleos(t)ide-naive patients randomized to at least 48 wk of treatment with entecavir 0.5 mg/day or lamivudine 100 mg/day. The third trial randomized lamivudine-refractory patients to 48 wk of entecavir 1 mg/day or lamivudine 100 mg/day. In this post hoc descriptive analysis, the efficacy and safety in patients with advanced liver fibrosis/cirrhosis (Ishak fibrosis stages 4-6) were examined for consistency with those seen in the overall study populations. Of the 1,633 treated patients, 245 had advanced liver fibrosis/cirrhosis (120 entecavir and 125 lamivudine). Among entecavir-treated patients with advanced liver fibrosis, improvement in Ishak fibrosis was observed in 57% of nucleos(t)ide-naive hepatitis B e antigen (HBeAg)-positive patients, 59% of nucleos(t)ide-naive HBeAg-negative patients, and 43% of lamivudine-refractory HBeAg-positive patients versus 49%, 53%, and 33% ...Continue Reading

References

Oct 8, 2004·The New England Journal of Medicine·Yun-Fan LiawUNKNOWN Cirrhosis Asian Lamivudine Multicentre Study Group
May 25, 2005·Liver International : Official Journal of the International Association for the Study of the Liver·Yun-Fan LiawUNKNOWN Asian-Pacific consensus update working party on chronic hepatitis B
Feb 4, 2006·Journal of Hepatology·Tim ShawStephen Locarnini
Mar 10, 2006·The New England Journal of Medicine·Ting-Tsung ChangUNKNOWN BEHoLD AI463022 Study Group
Mar 10, 2006·The New England Journal of Medicine·Ching-Lung LaiUNKNOWN BEHoLD AI463027 Study Group
Jun 10, 2006·Gastroenterology·Morris ShermanUNKNOWN AI463026 BEHoLD Study Group
Jul 18, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Emmet B KeeffeTeresa L Wright
Jan 30, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Anna S F Lok, Brian J McMahon
Jun 15, 2007·Orvosi hetilap·Beáta Gasztonyi
Jul 3, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Erik H C J BusterUNKNOWN HBV 99-01 Study Group
Nov 7, 2007·Gastroenterology·Robert G GishHelena Brett-Smith

❮ Previous
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Citations

Oct 4, 2011·The Journal of Antimicrobial Chemotherapy·James FungMan-Fung Yuen
Jun 23, 2011·Infection and Drug Resistance·Melissa Osborn
May 27, 2009·World Journal of Gastroenterology : WJG·Li JiangLu-Nan Yan
May 27, 2010·World Journal of Gastroenterology : WJG·Li Jiang, Lu-Nan Yan
Oct 24, 2013·World Journal of Gastroenterology : WJG·Xiao-Guang Ye, Qi-Min Su
Jan 11, 2014·World Journal of Gastroenterology : WJG·Evangelos Cholongitas, George V Papatheodoridis
Jul 12, 2012·Hepatitis Monthly·Mario Rizzetto
Mar 29, 2011·Scandinavian Journal of Gastroenterology·Ellen Sloth AndersenNina Weis
Apr 6, 2013·Expert Opinion on Pharmacotherapy·Matthew D SadlerSamuel S Lee
Jan 6, 2011·Expert Opinion on Biological Therapy·Mauro Viganò, Pietro Lampertico
Apr 6, 2016·Clinical and Molecular Hepatology·UNKNOWN Korean Association for the Study of the Liver
Feb 9, 2010·Journal of Hepatology·Sara RaimondiMario U Mondelli
Aug 4, 2009·Gastroenterología y hepatología·Marlene DomínguezRamón Bataller
Jun 13, 2014·Journal of Clinical Gastroenterology·Vignan ManneSammy Saab
May 26, 2017·European Journal of Gastroenterology & Hepatology·Pin-Chao WangChia-Chi Wang
Jul 29, 2017·Expert Review of Gastroenterology & Hepatology·Masako OkadaMindie H Nguyen
Nov 9, 2017·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Yuko NagaokiKazuaki Chayama
Oct 5, 2010·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Masaru EnomotoNorifumi Kawada
Jul 22, 2009·Liver International : Official Journal of the International Association for the Study of the Liver·George V PapatheodoridisAndrew K Burroughs
Nov 26, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Christian M LangeChristoph Sarrazin
Nov 4, 2009·Expert Review of Anti-infective Therapy·Stevan A Gonzalez, Emmet B Keeffe
Jan 25, 2013·World Journal of Surgery·Nam-Joon YiKyung-Suk Suh
Feb 5, 2015·Journal of Cancer Research and Clinical Oncology·Takanori ItoToshifumi Tada
Jun 2, 2016·Journal of Gastroenterology·Hiroshi FukuiTooru Shimosegawa
Apr 19, 2012·The Korean Journal of Hepatology·Ki Tae SukUNKNOWN Korean Association for the Study of the Liver
May 29, 2014·World Journal of Hepatology·Chrysoula Pipili, Evangelos Cholongitas
Sep 11, 2014·World Journal of Gastroenterology : WJG·Claus Niederau
Oct 11, 2011·Clinical Transplantation·Chang-jie CaiGui-hua Chen
Jan 11, 2012·Liver International : Official Journal of the International Association for the Study of the Liver·Jung-Ta KaoYi-Ying Wu
Aug 16, 2012·Clinical and Molecular Hepatology·UNKNOWN Korean Association for the Study of the Liver
Jun 23, 2020·Chinese Medical Journal·Ya-Meng SunHong You
Oct 15, 2013·Journal of Gastroenterology and Hepatology·Yin-Jie GaoHan-Wei Li
Apr 20, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yun-Fan LiawElizabeth Cooney
Jun 23, 2019·Clinical Drug Investigation·Yi ShenPengcheng Xun
Jun 6, 2009·Drugs·Lesley J Scott, Gillian M Keating
Aug 5, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ting-Tsung ChangBruce Kreter

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