Efficacy and safety of etodolac-paracetamol fixed dose combination in patients with knee osteoarthritis flare-up: a randomized, double-blind comparative evaluation

The Clinical Journal of Pain
Anil PareekGirish Bartakke

Abstract

To evaluate the efficacy and safety of etodolac-paracetamol combination in comparison with etodolac alone in patients with knee osteoarthritis (OA) flare-up. In this double-blind, double-dummy, randomized, comparative, multicentric, parallel group study, 220 patients of either sex in the age range of 40 to 70 years with an OA flare-up were randomized either to etodolac (300 mg)-paracetamol (500 mg) combination or etodolac (300 mg) alone twice a day for 10 days. Efficacy outcomes were an average daily pain intensity score on 11-point visual analog scale, Western Ontario and McMaster score (WOMAC), and Lequesne Severity Index; total pain relief score at 30 minutes, 1, 2, and 4 hours after first-dose administration; OA flare-up symptoms resolution; patient's and investigator's overall assessment of study treatments. Etodolac-paracetamol was significantly superior to etodolac alone in reducing pain intensity (P<0.001), achieving pain relief (P<0.05) during the first 4 hours after the study dose administration, and resolution of the clinical signs and symptoms of OA flare-up such as morning stiffness, swelling/inflammation, and erythema. The combination showed significantly greater improvement in WOMAC scores and Lequesne Severity I...Continue Reading

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Citations

Oct 12, 2012·Journal of Pain Research·Joseph V PergolizziRobert B Raffa
Jun 26, 2013·Expert Opinion on Drug Delivery·Julia L ShamshinaRobin D Rogers
Jan 13, 2015·Arthritis Care & Research·Susan L MurphyKristine Phillips
Dec 8, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Laixi JiJie Yang
Jul 22, 2018·BMJ Open·Emma L ParryGeorge Peat

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