Efficacy and safety of etomidate-midazolam for screening colonoscopy in the elderly: A prospective double-blinded randomized controlled study

Medicine
Jung Min LeeWoojung Kim

Abstract

Recent studies have shown that etomidate is associated with fewer serious adverse events than propofol and has a noninferior sedative effect. We investigated whether etomidate-midazolam is associated with fewer cardiopulmonary adverse events and has noninferior efficacy compared to propofol-midazolam for screening colonoscopy in the elderly. A prospective, single-center, double-blinded, randomized controlled trial was performed. Patients aged over 65 years who were scheduled to undergo screening colonoscopy were randomized to receive either etomidate or propofol based on midazolam. The primary outcome was all cardiopulmonary adverse events. The secondary outcomes were vital sign fluctuation (VSF), adverse events disturbing the procedure, and sedation-related outcomes. The incidence of cardiopulmonary adverse events was higher in the propofol group (72.6%) than in the etomidate group (54.8%) (P = .040). VSF was detected in 17 (27.4%) and 31 (50.0%) patients in the etomidate and propofol groups, respectively (P = .010). The incidence rate of adverse events disturbing the procedure was significantly higher in the etomidate group (25.8%) than in the propofol group (8.1%) (P = .008). Moreover, the incidence rate of myoclonus was sig...Continue Reading

References

Jan 3, 2001·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·W J RuthA J Bock
Jul 2, 2004·Gastrointestinal Endoscopy·Neena S AbrahamAlan N Barkun
Mar 28, 2006·Gastrointestinal Endoscopy·Waqar A QureshiUNKNOWN Standards of Practice Committee, American Society for Gastrointestinal Endoscopy
Aug 29, 2006·Journal of Perianesthesia Nursing : Official Journal of the American Society of PeriAnesthesia Nurses·Heather Ead
Aug 8, 2007·Gastroenterology·Lawrence B CohenUNKNOWN AGA Institute
Nov 6, 2008·Gastrointestinal Endoscopy·David R LichtensteinJohn J Vargo
Sep 28, 2010·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Atul SachdevaVijay Gupta
May 4, 2011·Internal and Emergency Medicine·Luigi BuriUNKNOWN SIED Appropriateness Working Group
Apr 6, 2013·The American Journal of Emergency Medicine·Adam M YatesThompson Kehrl
Jun 15, 2013·Clinical Endoscopy·Seong Hee Kang, Jong Jin Hyun
Aug 8, 2013·World Journal of Gastroenterology : WJG·Can-Xia XuXiao-Ming Liu
Jul 22, 2014·Anesthesia and Analgesia·Mary Ellen Warner, Mark A Warner
Jul 26, 2014·Endoscopy·F IgeaF Vida
May 8, 2015·Journal of Anaesthesiology, Clinical Pharmacology·Shagun Bhatia ShahBhawnish Sabbharwal
Dec 21, 2016·Annals of Emergency Medicine·Cameron P UpchurchWesley H Self
Jun 29, 2017·Medicine·Jinfeng LiuHuacheng Zhou
Aug 23, 2017·Gastrointestinal Endoscopy·John J Vargo

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Citations

Jun 2, 2021·Clinical Pharmacokinetics·Beatrijs I Valk, Michel M R F Struys
Jun 26, 2021·Digestive Diseases and Sciences·Brian M FungJames H Tabibian

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Methods Mentioned

BETA
sedation
biopsy

Software Mentioned

SPSS
PASS

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