Efficacy and safety of extended-release amantadine in levodopa-induced dyskinesias: a meta-analysis

Neurodegenerative Disease Management
Azalea T PajoRoland Dominic G Jamora

Abstract

Aim: To determine the effectiveness and safety of extended-release amantadine (ADS-5102) for levodopa-induced dyskinesias (LID) in patients with Parkinson disease (PD) by conducting a meta-analysis of relevant trials. Methods: The electronic databases were searched on or before March 1, 2019 for relevant trials. Only randomized, double-blind, parallel-group, placebo-controlled trials using ADS-5102 for LID in PD were included. Results: The ADS-5102 showed a reduction in the dyskinesia scores (mean difference: -9.56: CI: -10.05 to -9.07; p < 0.00001) and in the on time without troublesome dyskinesia (mean difference 2.50: CI 2.38 to 2.63; p < 0.00001). The adverse events identified in ADS-5102 were visual hallucinations, constipation, dry mouth and fall. Conclusion: ADS-5102 can be used as an adjunct therapy for LID.

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Citations

May 20, 2020·Science Advances·Mehdi EshraghiSrinivasa Subramaniam
Oct 6, 2020·Neurodegenerative Disease Management·Dominique Q PerezRoland Dominic G Jamora

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