Efficacy and safety of fludarabine and cyclophosphamide combined therapy in patients with refractory/recurrent B-cell chronic lymphocytic leukaemia (B-CLL)-Polish multicentre study

Leukemia & Lymphoma
M KowalM Komarnicki

Abstract

The aim of this study was to investigate the efficacy of a combination of fludarabine (F) and cyclophosphamide (C) in the treatment of patients with refractory/recurrent B-cell chronic lymphocytic leukaemia (B-CLL). Between November 1999 and December 2001, 63 patients with B-CLL (median age 60 years) received a regimen that consisted of F 25 mg/m2 and C 250 mg/m2, days 1-3, intravenously, every 4 weeks, for a maximum of 6 courses, Response and toxicity were assessed according to current criteria (NCI-WG and WHO). Complete and partial remissions were achieved in 17.5% and 55.6% of patients, respectively; 19% of patients had stable disease and 7.9% of patients showed disease progression. The median follow-up was 16.5 (range 1.5-32) months. The median duration of progression-free survival (PFS) has not been reached among patients treated with FC regimen as second-line therapy. The median PFS was 13 (range 8-26) months in the 19 responding patients treated with FC regimen as third-line therapy. The most frequent side-effects were neutropenia (45%), thrombocytopenia (42%) and infections (57%). We conclude that the combination of fludarabine and cyclophosphamide demonstrated significant efficacy in pretreated, advanced B-CLL patients...Continue Reading

References

Feb 1, 1996·Leukemia & Lymphoma·R SafadiA Eldor
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Oct 6, 2001·Blood·M LeporrierUNKNOWN French Cooperative Group on Chronic Lymphocytic Leukemia
Dec 11, 2002·British Journal of Haematology·Francesc BoschUNKNOWN GELCAB (Grup per l'Estudi dels Limfomes a Catalunya i Balears)

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Citations

Aug 21, 2007·Current Oncology Reports·Deepa Sampath, William Plunkett
Oct 30, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Vicki A Morrison
Dec 24, 2015·Leukemia & Lymphoma·Anat Gafter-Gvili, Aaron Polliack
Jun 22, 2013·Leukemia Research·Joshua Lukenbill, Matt Kalaycio
Jul 14, 2010·Best Practice & Research. Clinical Haematology·Vicki A Morrison
Jun 7, 2008·Veterinary Clinical Pathology·Janina Lukaszewska, Krzysztof Lewandowski

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