Efficacy and safety of high-dose budesonide/formoterol (Symbicort) compared with budesonide administered either concomitantly with formoterol or alone in patients with persistent symptomatic asthma

Respirology : Official Journal of the Asian Pacific Society of Respirology
Christine JenkinsEva Pettersson

Abstract

Budesonide/formoterol 160/4.5 microg, two inhalations bd, is an effective and well-tolerated maintenance therapy for patients not controlled on inhaled corticosteroids alone. The authors assessed the efficacy and safety of a higher dose of budesonide/formoterol in patients with persistent symptomatic asthma. This was a 24-week, double-blind, double-dummy randomized study. Budesonide/formoterol 320/9 microg, two inhalations bd (1280/36 microg/day), was compared with corresponding doses of budesonide during weeks 1-12 and budesonide plus formoterol via separate inhalers during weeks 1-24. Efficacy was assessed during weeks 1-12; the primary variable was morning PEF. Safety was assessed over weeks 1-24. Patients (n=456; aged 12-79 years) had a mean reversibility in FEV1 of 28% and mean pre-study inhaled corticosteroid dose of 1038 microg/day. Mean morning PEF increased by 37 L/min and 36 L/min with budesonide/formoterol and budesonide plus formoterol, respectively, versus an increase of 5 L/min with budesonide (P<0.001 for both vs. budesonide). Budesonide/formoterol increased time to first mild exacerbation (P<0.005) versus budesonide. Budesonide/formoterol and budesonide plus formoterol had similar efficacy. All treatments were w...Continue Reading

References

Feb 1, 1992·British Journal of Clinical Pharmacology·B J Lipworth, D G McDevitt
May 1, 1996·American Journal of Respiratory and Critical Care Medicine·A WoolcockL A Jacques
Feb 13, 2001·Pulmonary Pharmacology & Therapeutics·M PalmqvistJ Lötvall
May 23, 2001·JAMA : the Journal of the American Medical Association·S C LazarusUNKNOWN Asthma Clinical Research Network for the National Heart, Lung, and Blood Institute
Sep 1, 2001·The European Respiratory Journal·O ZetterströmT Ekström
Nov 13, 2001·American Journal of Respiratory and Critical Care Medicine·P M O'ByrneA Tattersfield
May 17, 2003·Pulmonary Pharmacology & Therapeutics·Jaro AnkerstEva Weibull
Nov 19, 2003·The European Respiratory Journal·R A PauwelsUNKNOWN RELIEF Study investigators
Dec 18, 2003·Canadian Respiratory Journal : Journal of the Canadian Thoracic Society·J Mark FitzGeraldUNKNOWN Canadian Investigators
May 5, 2004·Pulmonary Pharmacology & Therapeutics·Hanneke J van der WoudeRené Aalbers
Oct 27, 2004·American Journal of Respiratory and Critical Care Medicine·Paul M O'ByrneEric D Bateman
Mar 1, 1993·The European Respiratory Journal·P H QuanjerJ C Yernault

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Citations

Oct 15, 2010·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Geoff K Frampton, Jonathan Shepherd
Jan 9, 2007·Respirology : Official Journal of the Asian Pacific Society of Respirology·Y C Gary Lee, Richard Beasley
Jan 18, 2012·Respirology : Official Journal of the Asian Pacific Society of Respirology·Makoto Hoshino, Junichi Ohtawa
Feb 18, 2010·The Journal of Allergy and Clinical Immunology·Harold NelsonCraig LaForce
Feb 13, 2007·The Journal of Allergy and Clinical Immunology·Peter G GibsonFrancine M Ducharme
Sep 9, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jill R JohnsonManel Jordana
Sep 26, 2019·The Cochrane Database of Systematic Reviews·Sadia JanjuaChristopher J Cates
Mar 13, 2020·International Journal of Chronic Obstructive Pulmonary Disease·Shiyuan ZhangAfisi S Ismaila
Jun 8, 2013·The Cochrane Database of Systematic Reviews·Christopher J CatesMontse Ferrer

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