Efficacy and Safety of Ibuprofen in Infants Aged Between 3 and 6 Months

Paediatric Drugs
Victoria C ZiesenitzJohannes N van den Anker

Abstract

Ibuprofen is a non-steroidal anti-inflammatory drug frequently administered to children of various ages for relief of fever and pain and is approved as an over-the-counter medication in many countries worldwide. Although there are extensive data on its efficacy and safety in children and adults, there are divergent dosing recommendations for analgesia and treatment of fever in infants, especially in the age group between 3 and 6 months of age. In this article, we have assessed the safety and efficacy of ibuprofen use in infants in an attempt to find the optimal method of pain and fever management in this specific age group. Based on the current evidence, short-term use of ibuprofen is considered safe in infants older than 3 months of age having a body weight above 5-6 kg when special attention is given to the hydration of the patient. Ibuprofen should be prescribed based on body weight using a dose of 5-10 mg/kg. This dose can be administered 3-4 times a day resulting in a maximum total daily dose of 30-40 mg/kg. The rectal route has been shown to be less reliable because of erratic absorption, especially in young infants. Since most efficacy and safety data have been derived from trials in infants with fever, future studies sh...Continue Reading

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Citations

Jan 17, 2019·Clinical Pharmacology and Therapeutics·Frédérique RodieuxCaroline F Samer
Sep 1, 2019·Paediatric Anaesthesia·Brian J Anderson, Jacqueline A Hannam
Aug 10, 2019·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Brady S MoffettNathaniel Strobel
Dec 24, 2018·Minerva pediatrica·Massimo Barbagallo, Paola Sacerdote
Apr 30, 2021·African Journal of Emergency Medicine : Revue Africaine De La Médecine D'urgence·Robin GreenFatima Mustafa
May 11, 2021·Current Medical Research and Opinion·Ian M Paul, Philip D Walson
Jun 16, 2019·International Journal of Pediatric Otorhinolaryngology·Reena RazdanMichele M Carr
Nov 6, 2021·European Journal of Pediatrics·Romy TilenChristoph Berger

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