Efficacy and safety of intracavernosal alprostadil in men with erectile dysfunction. The Alprostadil Study Group

The New England Journal of Medicine
O I Linet, F G Ogrinc

Abstract

Erectile dysfunction is a common medical problem affecting many men. Although several intracavernosal therapies are available, their efficacy and safety have not been studied systematically. We investigated the efficacy and safety of alprostadil formulated for intracavernosal treatment in three separate multi-institutional, prospective studies in men with erectile dysfunction of vasculogenic, neurogenic, psychogenic, and mixed causes. Clinical and laboratory evaluations of erection and the feasibility of satisfactoriness of sexual activity as assessed both by the men and by their partners were the primary measures of efficacy. In a dose-response study of 296 men, all doses of alprostadil were superior to placebo and there was a significant dose-response relation (P < / = 0.001), resulting in higher response rates with increasing doses of alprostadil (from 2.5 to 20 microg). In a dose-finding study of 201 men, the minimal effective dose was < / = 2 microg in 23, 20, 38 and 23 percent of men with erectile dysfunction of neurogenic, vasculogenic, psychogenic, or mixed causes, respectively. In a six-month self-injection study in 683 men, the participants reported being able to have sexual activity after 94 percent of the injections...Continue Reading

References

Sep 1, 1991·The Journal of Urology·G S Gerber, L A Levine
Oct 1, 1991·The Journal of Urology·M B LindsayL T Kurland
Jan 1, 1989·European Urology·M ZentgrafM Ziegler
Dec 14, 1989·The New England Journal of Medicine·R J KraneI Saenz de Tejada
Nov 1, 1989·British Journal of Clinical Pharmacology·P Schramek, M Waldhauser
Jul 1, 1988·The Journal of Urology·W StacklM Marberger
May 1, 1987·The Journal of Urology·R Virag, P G Adaikan
Nov 1, 1983·Journal of Clinical Pharmacology·R J CapetolaJ L McGuire
Jan 1, 1994·The Clinical Investigator·O I Linet, L L Neff
Dec 1, 1993·The Journal of Urology·B von HeydenT F Lue
May 1, 1993·The British Journal of Radiology·Z AminW R Lees
Jul 7, 1993·JAMA : the Journal of the American Medical Association

❮ Previous
Next ❯

Citations

Jan 1, 1997·World Journal of Urology·K E Andersson, C G Stief
Jan 5, 2002·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·T F Lue
Oct 30, 2003·Aging Clinical and Experimental Research·Gaetano Frajese, Flavio Pozzi
Dec 10, 2009·Wiener medizinische Wochenschrift·Brigitte Esterbauer, Andreas Jungwirth
Dec 21, 2000·Current Psychiatry Reports·R T Segraves
Jun 27, 2002·Current Urology Reports·C C Carson
Jun 27, 2002·Current Urology Reports·A Nehra
Oct 22, 2005·Current Urology Reports·Culley C CarsonEric Wallen
Feb 9, 2006·Current Treatment Options in Neurology·Christopher H Gibbons, Roy Freeman
Mar 19, 2004·The Journal of Emergency Medicine·Gary M VilkeTheodore C Chan
Jan 4, 2001·The American Journal of Medicine·L A Levine
Jan 4, 2001·The American Journal of Medicine·R A Kloner
Feb 13, 1999·Disease-a-month : DM·M E Wierman
May 30, 2001·Urology·E FagelmanR Shabsigh
Nov 4, 1998·Urology·K S AnsongJ Bell
Jul 12, 2002·The Urologic Clinics of North America·Mark A Moyad
Jul 6, 2000·Neuroscience and Biobehavioral Reviews·R C Rosen, B D Sachs
Dec 21, 2000·Trends in Pharmacological Sciences·T J BivalacquaP J Kadowitz
Apr 1, 1997·Trends in Endocrinology and Metabolism : TEM·A M Robinson, R E Ryder
Sep 3, 2010·International Journal of Impotence Research·G YangJ Lu
Mar 7, 2002·British Journal of Clinical Pharmacology·Peter A MilliganMats O Karlsson
Mar 16, 2000·Clinical Endocrinology·A LevyC Gingell
May 23, 1998·British Journal of Urology·J C Gingell
Jul 17, 1998·British Journal of Urology·C BettocchiD J Ralph
Dec 5, 1998·British Journal of Urology·N Oakley, K T Moore
Apr 4, 1996·The New England Journal of Medicine·L I Lipshultz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.