PMID: 9184705Jun 1, 1997Paper

Efficacy and safety of intravenous phosphate replacement in critically ill patients

The Annals of Pharmacotherapy
M M PerreaultM G Tierney

Abstract

To evaluate the efficacy and safety of intravenous potassium phosphate administered in a fixed-dose regimen in critically ill patients. Prospective, unblind study. Surgical-medical intensive care unit (ICU). Patients who developed hypophosphatemia during their ICU admission. Patients with a serum phosphate concentration between 1.27 and 2.48 mg/dL (group 1) and those with a concentration of 1.24 mg/dL or less (group 2) received 15 and 30 mmol, respectively, of phosphate as a potassium salt via a central line over 3 hours. Normalization of serum phosphate within 6 hours of infusion, the development of arrhythmias during the infusion, and the development of hypocalcemia and hyperkalemia after the infusion were evaluated. Redevelopment of hypophosphatemia and the need for further therapy were also assessed. Thirty-seven episodes of hypophosphatemia were entered in this study: 27 in group 1 (17 patients) and 10 in group 2 (10 patients). The mean serum phosphate concentration increased significantly from 2.02 to 2.82 mg/dL in group 1 and from 0.83 to 2.17 mg/dL in group 2, with no change in calcium or potassium. Normalization of serum phosphate with this initial dose occurred in 81.5% of the episodes in group 1 and 30% in group 2. H...Continue Reading

References

Dec 1, 1978·Annals of Internal Medicine·R D LentzC M Kjellstrand
Mar 1, 1988·The American Journal of the Medical Sciences·S V DavisS C Chakko
Aug 15, 1985·The New England Journal of Medicine·M AubierR Pariente
Jan 1, 1985·Critical Care Medicine·M Kingston, M B Al-Siba'i
Jun 20, 1974·The New England Journal of Medicine·P R CraddockH S Jacob
Nov 1, 1983·Southern Medical Journal·J B VannattaS Papper
Mar 1, 1981·The American Journal of Clinical Nutrition·R L Weinsier, C L Krumdieck
May 1, 1994·The Annals of Pharmacotherapy·G R Brown, J K Greenwood

❮ Previous
Next ❯

Citations

Jun 13, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·N AgrawalC P Thomas
Jan 8, 2015·JPEN. Journal of Parenteral and Enteral Nutrition·Laura L Frank
Aug 31, 2019·Journal of Clinical Pathology·Jenny Leung, Martin Crook
Jul 12, 2018·European Journal of Gastroenterology & Hepatology·Gonçalo NunesJorge Fonseca
Jun 27, 2019·Journal of Animal Physiology and Animal Nutrition·Patrick A Walsh, Daniel J O'Donovan
Oct 7, 2006·Current Opinion in Gastroenterology·D H Alpers, S Klein
Oct 5, 2010·Gastroenterology Research and Practice·L U R KhanJ Macfie
Dec 4, 2020·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Annika Reintam BlaserMette M Berger
Mar 23, 2005·Critical Care Clinics·Jean-Philippe Lafrance, Martine Leblanc

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.