Efficacy and safety of iodopovidone pleurodesis in malignant pleural effusions

Respirology : Official Journal of the Asian Pacific Society of Respirology
Jose D A NetoRicardo Mingarini Terra

Abstract

Pleurodesis is one of the best methods of controlling malignant pleural effusions (MPE), a distressing complication of metastatic disease. In recent studies of a wide range of pleural diseases, iodopovidone was used as a sclerosing agent for pleurodesis and demonstrated good results with low morbidity. The aim of this study was to evaluate the efficacy and safety of iodopovidone pleurodesis in MPE. A retrospective analysis was performed on patients with MPE who underwent pleurodesis at our institution between 2005 and 2008. All patients underwent instillation of 20 mL of 10% iodopovidone, 80 mL of normal saline and 2 mg/kg of lidocaine through a chest tube, which was clamped for 2 h. The tube was removed when the daily output of fluid was <200 mL. Data on the requirement for additional pleural procedures, adverse events and survival were collected. Sixty-one pleurodesis procedures were performed in 54 patients. No procedure-related mortality was observed. Adverse events occurred after 11 (18%) pleurodesis procedures. The most frequent complication was mild thoracic pain that occurred immediately after 10 (16.4%) procedures, and one patient developed pleural empyema that was treated with drainage and antibiotics. A success rate ...Continue Reading

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Citations

Apr 27, 2011·Current Opinion in Pulmonary Medicine·Francisco Rodriguez-Panadero, Beatriz Romero-Romero
Mar 5, 2010·Respirology : Official Journal of the Asian Pacific Society of Respirology·Andreas H Diacon
Nov 4, 2010·Respirology : Official Journal of the Asian Pacific Society of Respirology·Georgios T Stathopoulos
Feb 1, 2011·Respirology : Official Journal of the Asian Pacific Society of Respirology·Chi Chiu LeungStephen G Spiro
Jul 28, 2011·Respirology : Official Journal of the Asian Pacific Society of Respirology·Ioannis Kalomenidis
Mar 9, 2017·Expert Review of Respiratory Medicine·José M PorcelY C Gary Lee
Jan 31, 2012·Respiration; International Review of Thoracic Diseases·Francisco Rodriguez-Panadero, Ana Montes-Worboys
May 25, 2018·Asian Cardiovascular & Thoracic Annals·Reza BagheriMaryam Salehi
Jan 31, 2021·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Valliappan MuthuRitesh Agarwal

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