Efficacy and safety of jollab to treat functional dyspepsia: a randomized placebo-controlled clinical trial

Explore : the Journal of Science and Healing
Mehdi PasalarKamran Bagheri Lankarani

Abstract

Functional dyspepsia (FD) is a common gastrointestinal disease that is highly prevalent worldwide. Because of its heterogeneous pathophysiology, treatment options for FD can be difficult to choose; in this context, complementary and alternative medicine modalities have been suggested as promising options. To evaluate the efficacy of a traditional Persian medicine, jollab, in reducing patients' FD symptoms. In a double-blind randomized clinical trial, 160 patients with a diagnosis of FD were enrolled and treated with either jollab or placebo (15ml, t.i.d., four weeks, orally). The outcomes reported were changes in symptom frequency and severity as recorded in patients' diaries and evaluated with the Short Form of the Leeds Dyspepsia Questionnaire (SF-LDQ), and physical examination. The response rate was higher in the treatment group (78%) than in the placebo group (31%) according to per-protocol sample analysis (P < .001). Symptoms of FD disappeared significantly more frequently, and the rate of concomitant synthetic drug consumption was significantly lower, in the jollab group compared to the placebo group at the end of the trial. Mean total symptom frequency and severity according to the SF-LDQ score was 1.55 ± 2.78 in the tre...Continue Reading

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Citations

Nov 7, 2016·Journal of Ethnopharmacology·Maryam Mosaffa-JahromiAli-Mohammad Tamaddon
Jul 21, 2016·Journal of Pediatric Gastroenterology and Nutrition·Claudio RomanoMarc A Benninga
Nov 2, 2019·Journal of Gastroenterology and Hepatology·Niandi TanYinglian Xiao
Sep 15, 2020·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Ghazaleh HeydariradMehdi Pasalar
Nov 30, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Lijing YanXinjian Qiu
Mar 23, 2021·Advanced Pharmaceutical Bulletin·Mehdi PasalarKamran Bagheri Lankarani
Aug 18, 2021·The American Journal of Gastroenterology·Xinyi HuangHiroto Miwa
May 28, 2019·Complementary Medicine Research·Ghazaleh HeydariradHamid Reza Mirzaei

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