Efficacy and Safety of L-Carnitine Treatment for Chronic Heart Failure: A Meta-Analysis of Randomized Controlled Trials

BioMed Research International
Xiaolong SongHua Zhou

Abstract

Background . Whether additional benefit can be achieved with the use of L-carnitine (L-C) in patients with chronic heart failure (CHF) remains controversial. We therefore performed a meta-analysis of randomized controlled trials (RCTs) to evaluate the effects of L-C treatment in CHF patients.Methods. Pubmed, Ovid Embase, Web of Science, and Cochrane Library databases, Chinese National Knowledge Infrastructure (CNKI) database, Wanfang database, Chinese Biomedical (CBM) database, and Chinese Science and Technology Periodicals database (VIP) until September 30, 2016, were identified. Studies that met the inclusion criteria were systematically evaluated by two reviewers independently.Results. 17 RCTs with 1625 CHF patients were included in this analysis. L-C treatment in CHF was associated with considerable improvement in overall efficacy (OR = 3.47,P< 0.01), left ventricular ejection fraction (LVEF) (WMD: 4.14%,P= 0.01), strike volume (SV) (WMD: 8.21 ml,P= 0.01), cardiac output (CO) (WMD: 0.88 L/min,P< 0.01), and E/A (WMD: 0.23,P< 0.01). Moreover, treatment with L-C also resulted in significant decrease in serum levels of BNP (WMD: -124.60 pg/ml,P= 0.01), serum levels of NT-proBNP (WMD: -510.36 pg/ml,P< 0.01), LVESD (WMD: -4.06 mm...Continue Reading

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Citations

Mar 17, 2020·Nutrition Research Reviews·Arrigo F G CiceroUNKNOWN International Lipid Expert Panel
Dec 13, 2019·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Esmaeil Yousefi RadSomayeh Saboori
Jun 20, 2020·Journal of Pediatric Hematology/oncology·Mohsen ShahidiBorhan Moradveisi
May 13, 2020·Nutrients·Christopher PapandreouAouatef Bellamine
Dec 22, 2020·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Giovanni PaganoMarco Trifuoggi
Jan 18, 2021·American Heart Journal·Muhammad Zubair IsrarToru Suzuki
Feb 14, 2020·Critical Pathways in Cardiology·Sogand GoudarziGerald Chi
Feb 22, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Mahnaz SalmaniHossein Imani
May 4, 2021·Frontiers in Bioengineering and Biotechnology·Pierre KuglerVolker F Wendisch
Jun 15, 2021·Current Research in Food Science·Alicia Lopez-MaldonadoJosé Ángel Rufián-Henares
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Apr 17, 2021·Expert Review of Clinical Pharmacology·Dong-Dong WangXiao Chen
May 16, 2019·Terapevticheskiĭ arkhiv·Zh M SizovaA A Makhova
Dec 21, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Chennan WuXia Liu

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